Gene
mdh1ab
- ID
- ZDB-GENE-030131-7655
- Name
- malate dehydrogenase 1Ab, NAD (soluble)
- Symbol
- mdh1ab Nomenclature History
- Previous Names
-
- MDH1a (1)
- mdh1b
- fk59d03
- wu:fk59d03
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have L-malate dehydrogenase activity. Predicted to be involved in carbohydrate metabolic process; malate metabolic process; and tricarboxylic acid cycle. Is expressed in several structures, including cardiovascular system; mesoderm; musculature system; retinal photoreceptor layer; and solid lens vesicle. Orthologous to human MDH1 (malate dehydrogenase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6907737 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 88 | Alliance | ?Developmental and epileptic encephalopathy 88 | 618959 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR001252 | Malate dehydrogenase, active site |
| Domain | IPR001236 | Lactate/malate dehydrogenase, N-terminal |
| Domain | IPR022383 | Lactate/malate dehydrogenase, C-terminal |
| Family | IPR001557 | L-lactate/malate dehydrogenase |
| Family | IPR010945 | Malate dehydrogenase, type 2 |
| Family | IPR011274 | Malate dehydrogenase, NAD-dependent, cytosolic |
| Homologous_superfamily | IPR015955 | Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal | Lactate/malate dehydrogenase, C-terminal | Lactate/malate dehydrogenase, N-terminal | L-lactate/malate dehydrogenase | Malate dehydrogenase, active site | Malate dehydrogenase, NAD-dependent, cytosolic | Malate dehydrogenase, type 2 | NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7ZSY2
|
333 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| pseudogenic transcript |
mdh1ab-201
(1)
|
Ensembl | 1,724 nt |
Interactions and Pathways
No data available
Plasmids
No data available