Gene

mak

ID

ZDB-GENE-030131-7279

Name

male germ cell-associated kinase

Symbol

mak Nomenclature History

Previous Names

fj04c02
wu:fj04c02
zgc:56603 (1)

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to have protein serine/threonine kinase activity. Predicted to be involved in cilium organization; intracellular signal transduction; and regulation of gene expression. Predicted to localize to cilium; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in retinitis pigmentosa 62. Is expressed in Kupffer's vesicle; retina; and retinal photoreceptor layer. Orthologous to human MAK (male germ cell associated kinase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56603 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Tucker et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mak Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
retinitis pigmentosa 62	Alliance	Retinitis pigmentosa 62	614181

Associated With mak Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Family	IPR050117	Mitogen-activated protein kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Length	Mitogen-activated protein kinase	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site
UniProtKB:F1QUT2 InterPro	633
UniProtKB:A0A8M9PFV2 InterPro	590
UniProtKB:A0A8M3ANF8 InterPro	600
UniProtKB:A0A8M2B9R2 InterPro	601
UniProtKB:Q7ZTX0 InterPro	633
UniProtKB:A0A286Y937 InterPro	632

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	mak-201 (1) Ensembl	Ensembl		2,423 nt	Select Tool ZFIN BLAST
mRNA	mak-202 (1) Ensembl	Ensembl		2,420 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations