Gene

tubb2b

ID

ZDB-GENE-030131-722

Name

tubulin, beta 2b

Symbol

tubb2b Nomenclature History

Previous Names

fb40f09
wu:fb40f09 (1)
zgc:123194

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have GTP binding activity. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to localize to cytoplasm and microtubule. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 7. Orthologous to human TUBB2B (tubulin beta 2B class IIb).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tubb2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
complex cortical dysplasia with other brain malformations 7	Alliance	Cortical dysplasia, complex, with other brain malformations 7	610031

Associated With tubb2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017975	Tubulin, conserved site
Domain	IPR003008	Tubulin/FtsZ, GTPase domain
Domain	IPR018316	Tubulin/FtsZ, 2-layer sandwich domain
Family	IPR000217	Tubulin
Family	IPR002453	Beta tubulin
Homologous_superfamily	IPR008280	Tubulin/FtsZ, C-terminal
Homologous_superfamily	IPR023123	Tubulin, C-terminal
Homologous_superfamily	IPR036525	Tubulin/FtsZ, GTPase domain superfamily
Homologous_superfamily	IPR037103	Tubulin/FtsZ-like, C-terminal domain