Gene
spry2
- ID
- ZDB-GENE-030131-7038
- Name
- sprouty RTK signaling antagonist 2
- Symbol
- spry2 Nomenclature History
- Previous Names
-
- wu:fk66h11
- wu:fk93e11
- zgc:110440
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Involved in blood vessel development; dorsal/ventral pattern formation; and negative regulation of fibroblast growth factor receptor signaling pathway. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Is expressed in several structures, including brain; forerunner cell group; hindbrain neural keel; midbrain hindbrain boundary neural keel; and sensory system. Orthologous to human SPRY2 (sprouty RTK signaling antagonist 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Labalette et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {?IgA nephropathy, susceptibility to, 3} | 616818 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR007875 | Sprouty |
Domain Details Per Protein
| Protein | Length | Sprouty |
|---|---|---|
|
UniProtKB:F1QU39
|
301 | |
|
UniProtKB:Q4VBS7
|
301 |
Interactions and Pathways
No data available
Plasmids
No data available