Gene
rapgef2b
- ID
- ZDB-GENE-030131-6959
- Name
- Rap guanine nucleotide exchange factor 2b
- Symbol
- rapgef2b Nomenclature History
- Previous Names
-
- rapgef2
- fa11h07
- wu:fa11h07
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to have GTPase activator activity and Rap guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of GTPase activity; regulation of cell population proliferation; and small GTPase mediated signal transduction. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 7. Orthologous to human RAPGEF2 (Rap guanine nucleotide exchange factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ebarasi et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
familial adult myoclonic epilepsy 7 | Alliance | ?Epilepsy, familial adult myoclonic, 7 | 618075 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000159 | Ras-associating domain |
Domain | IPR000595 | Cyclic nucleotide-binding domain |
Domain | IPR000651 | Ras-like guanine nucleotide exchange factor, N-terminal |
Domain | IPR001478 | PDZ domain |
Domain | IPR001895 | Ras guanine-nucleotide exchange factors catalytic domain |
Homologous_superfamily | IPR014710 | RmlC-like jelly roll fold |
Homologous_superfamily | IPR018490 | Cyclic nucleotide-binding domain superfamily |
Homologous_superfamily | IPR023578 | Ras guanine nucleotide exchange factor domain superfamily |
Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
Homologous_superfamily | IPR036034 | PDZ superfamily |
Homologous_superfamily | IPR036964 | Ras guanine-nucleotide exchange factor, catalytic domain superfamily |
Domain Details Per Protein
Protein | Length | Cyclic nucleotide-binding domain | Cyclic nucleotide-binding domain superfamily | PDZ domain | PDZ superfamily | Ras-associating domain | Ras guanine-nucleotide exchange factor, catalytic domain superfamily | Ras guanine nucleotide exchange factor domain superfamily | Ras guanine-nucleotide exchange factors catalytic domain | Ras-like guanine nucleotide exchange factor, N-terminal | RmlC-like jelly roll fold | Ubiquitin-like domain superfamily |
---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A2R8QLQ3
|
1607 | |||||||||||
UniProtKB:A0A8M3ASA2
|
1538 | |||||||||||
UniProtKB:A0A8M6Z2S8
|
1629 | |||||||||||
UniProtKB:A0A8M6Z9Y2
|
1626 | |||||||||||
UniProtKB:A0A8M6Z291
|
1473 | |||||||||||
UniProtKB:A0A8M6Z9Y5
|
1518 | |||||||||||
UniProtKB:A0A8M6Z4A7
|
1601 | |||||||||||
UniProtKB:A0A8M6Z2T1
|
1604 | |||||||||||
UniProtKB:A0A8M6Z9J4
|
1634 | |||||||||||
UniProtKB:A0A0R4IBW6
|
1618 | |||||||||||
UniProtKB:A0A8M6Z4A2
|
1628 | |||||||||||
UniProtKB:A0A8M6Z286
|
1612 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA |
rapgef2-201
(1)
|
Havana | 6517 nt | |
mRNA |
rapgef2-204
(1)
|
Havana | 897 nt | |
mRNA |
rapgef2-206
(1)
|
Ensembl | 9514 nt | |
mRNA |
rapgef2-207
(1)
|
Ensembl | 9487 nt | |
mRNA |
rapgef2-208
(1)
|
Ensembl | 9210 nt | |
mRNA |
rapgef2-209
(1)
|
Ensembl | 9067 nt | |
mRNA |
rapgef2-210
(1)
|
Ensembl | 9037 nt | |
mRNA |
rapgef2-211
(1)
|
Ensembl | 9550 nt | |
ncRNA |
rapgef2-003
(1)
|
Havana | 772 nt | |
ncRNA |
rapgef2-004
(1)
|
Havana | 307 nt |
Interactions and Pathways
No data available
Plasmids
No data available