Gene
yars2
- ID
- ZDB-GENE-030131-6268
- Name
- tyrosyl-tRNA synthetase 2, mitochondrial
- Symbol
- yars2 Nomenclature History
- Previous Names
-
- fi41d10
- wu:fi41d10
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to have tyrosine-tRNA ligase activity. Predicted to be involved in tRNA aminoacylation. Predicted to localize to cytosol and mitochondrion. Human ortholog(s) of this gene implicated in myopathy, lactic acidosis, and sideroblastic anemia 2. Orthologous to human YARS2 (tyrosyl-tRNA synthetase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
myopathy, lactic acidosis, and sideroblastic anemia 2 | Alliance | Myopathy, lactic acidosis, and sideroblastic anemia 2 | 613561 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR001412 | Aminoacyl-tRNA synthetase, class I, conserved site |
Family | IPR002305 | Aminoacyl-tRNA synthetase, class Ic |
Family | IPR002307 | Tyrosine-tRNA ligase |
Family | IPR024088 | Tyrosine-tRNA ligase, bacterial-type |
Family | IPR024107 | Tyrosine-tRNA ligase, bacterial-type, type 1 |
Homologous_superfamily | IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
Homologous_superfamily | IPR036986 | RNA-binding S4 domain superfamily |
Domain Details Per Protein
Protein | Length | Aminoacyl-tRNA synthetase, class Ic | Aminoacyl-tRNA synthetase, class I, conserved site | RNA-binding S4 domain superfamily | Rossmann-like alpha/beta/alpha sandwich fold | Tyrosine-tRNA ligase | Tyrosine-tRNA ligase, bacterial-type | Tyrosine-tRNA ligase, bacterial-type, type 1 |
---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9PUY4
|
309 | |||||||
UniProtKB:F1Q4R5
|
474 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
antisense |
ottdart00000056263
(1)
|
Havana | 712 nt | |
mRNA |
yars2-201
(1)
|
Havana | 1794 nt |
Interactions and Pathways
No data available
Plasmids
No data available