Gene
brf1b
- ID
- ZDB-GENE-030131-6248
- Name
- BRF1 general transcription factor IIIB subunit b
- Symbol
- brf1b Nomenclature History
- Previous Names
-
- fi40c10
- wu:fi40c10
- zgc:63497
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have RNA polymerase III general transcription initiation factor activity and RNA polymerase III type 3 promoter sequence-specific DNA binding activity. Involved in cerebellum development and thrombocyte differentiation. Predicted to localize to nucleus; transcription factor TFIIIB complex; and transcription preinitiation complex. Is expressed in head. Orthologous to human BRF1 (BRF1 RNA polymerase III transcription initiation factor subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cerebellofaciodental syndrome | Alliance | Cerebellofaciodental syndrome | 616202 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR011665 | Brf1, TBP-binding domain |
| Domain | IPR013137 | Zinc finger, TFIIB-type |
| Domain | IPR013150 | Transcription factor TFIIB, cyclin-like domain |
| Domain | IPR013763 | Cyclin-like domain |
| Family | IPR000812 | Transcription factor TFIIB |
| Homologous_superfamily | IPR036915 | Cyclin-like superfamily |
Domain Details Per Protein
| Protein | Length | Brf1, TBP-binding domain | Cyclin-like domain | Cyclin-like superfamily | Transcription factor TFIIB | Transcription factor TFIIB, cyclin-like domain | Zinc finger, TFIIB-type |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6P9Z3
|
693 |
Interactions and Pathways
No data available
Plasmids
No data available