Gene

mark3a

ID

ZDB-GENE-030131-6232

Name

MAP/microtubule affinity-regulating kinase 3a

Symbol

mark3a Nomenclature History

Previous Names

mark3
fi39g08
wu:fi39g08
zgc:152848
zgc:55693 (1)

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to have protein serine/threonine kinase activity and tau-protein kinase activity. Predicted to be involved in intracellular signal transduction and microtubule cytoskeleton organization. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in visual impairment and progressive phthisis bulbi. Orthologous to human MARK3 (microtubule affinity regulating kinase 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55693 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mark3a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
visual impairment and progressive phthisis bulbi	Alliance	?Visual impairment and progressive phthisis bulbi	618283

Associated With mark3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR001772	Kinase associated domain 1 (KA1)
Domain	IPR015940	Ubiquitin-associated domain
Domain	IPR049508	Serine/threonine-protein kinase MARK 1-4, catalytic domain
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR028375	KA1 domain/Ssp2, C-terminal

Domain Details Per Protein

Protein	Length	KA1 domain/Ssp2, C-terminal	Kinase associated domain 1 (KA1)	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site	Serine/threonine-protein kinase MARK 1-4, catalytic domain	Ubiquitin-associated domain
UniProtKB:A0A8M9Q9J6 InterPro	678
UniProtKB:A0A8M9QF87 InterPro	669
UniProtKB:A0A8M9QNA7 InterPro	667
UniProtKB:A0A8M9PXN3 InterPro	746
UniProtKB:A0A8M2B2R7 InterPro	693
UniProtKB:E9QEM6 InterPro	737
UniProtKB:A0A2R8QKT7 InterPro	731
UniProtKB:Q802W0 InterPro	722
UniProtKB:A0A8M2B2Y7 InterPro	684

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mark3a-201 (1) Ensembl	Ensembl	3,396 nt	Select Tool
mRNA	mark3a-202 (1) Ensembl	Ensembl	2,214 nt	Select Tool ZFIN BLAST
mRNA	mark3a-203 (1) Ensembl	Ensembl	2,430 nt	Select Tool
mRNA	mark3a-204 (1) Ensembl	Ensembl	659 nt	Select Tool
mRNA	mark3a-205 (1) Ensembl	Ensembl	974 nt	Select Tool
mRNA	mark3a-206 (1) Ensembl	Ensembl	802 nt	Select Tool
mRNA	mark3a-207 (1) Ensembl	Ensembl	721 nt	Select Tool
mRNA	mark3a-209 (1) Ensembl	Ensembl	2,115 nt	Select Tool ZFIN BLAST
mRNA	mark3a-210 (1) Ensembl	Ensembl	2,196 nt	Select Tool ZFIN BLAST
ncRNA	mark3a-002 (1) Ensembl	Ensembl	721 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations