Gene

arhgef10

ID

ZDB-GENE-030131-6210

Name

Rho guanine nucleotide exchange factor (GEF) 10

Symbol

arhgef10 Nomenclature History

Previous Names

wu:fi38h08

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in actin cytoskeleton organization; mitotic spindle assembly; and positive regulation of stress fiber assembly. Predicted to be active in centrosome and cytoplasm. Human ortholog(s) of this gene implicated in alcohol-related birth defects. Orthologous to human ARHGEF10 (Rho guanine nucleotide exchange factor 10).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With arhgef10 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Slowed nerve conduction velocity, AD	608236

Associated With arhgef10 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR039919	Rho guanine nucleotide exchange factor 10/17
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M3AJ04	InterPro	1412
UniProtKB:A0A8M9Q2J2	InterPro	1411
UniProtKB:A0A8M9PCU5	InterPro	1373
UniProtKB:A0A8M9PLF3	InterPro	1412
UniProtKB:A0A8M3B2F6	InterPro	1373

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	arhgef10-201 (1) Ensembl	Ensembl	3,720 nt	Select Tool ZFIN BLAST
mRNA	arhgef10-202 (1) Ensembl	Ensembl	4,004 nt	Select Tool ZFIN BLAST
ncRNA	arhgef10-002 (1) Ensembl	Ensembl	780 nt	Select Tool ZFIN BLAST
ncRNA	arhgef10-003 (1) Ensembl	Ensembl	296 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations