Gene

agk

ID

ZDB-GENE-030131-6202

Name

acylglycerol kinase

Symbol

agk Nomenclature History

Previous Names

fi38e09
mulk
wu:fi38e09
zgc:55462 (1)

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to have acylglycerol kinase activity and diacylglycerol kinase activity. Predicted to be involved in protein insertion into mitochondrial inner membrane. Predicted to localize to TIM22 mitochondrial import inner membrane insertion complex; integral component of mitochondrial inner membrane; and mitochondrial intermembrane space. Human ortholog(s) of this gene implicated in Sengers syndrome and cataract 38. Orthologous to human AGK (acylglycerol kinase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55462 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With agk Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cataract 38	Alliance	Cataract 38, autosomal recessive	614691
Sengers syndrome	Alliance	Sengers syndrome	212350

Associated With agk Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001206	Diacylglycerol kinase, catalytic domain
Domain	IPR045579	Acylglycerol kinase, C-terminal
Family	IPR050187	Lipid Phosphate Formation and Regulation
Homologous_superfamily	IPR016064	NAD kinase/diacylglycerol kinase-like domain superfamily
Homologous_superfamily	IPR017438	Inorganic polyphosphate/ATP-NAD kinase, N-terminal