Gene
rnf168
- ID
- ZDB-GENE-030131-6013
- Name
- ring finger protein 168
- Symbol
- rnf168 Nomenclature History
- Previous Names
-
- fi30d02
- wu:fi30d02
- zgc:64185 (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to have several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; ubiquitin binding activity; and ubiquitin-protein transferase activity. Predicted to be involved in several processes, including DNA metabolic process; histone H2A ubiquitination; and regulation of nucleobase-containing compound metabolic process. Predicted to localize to nucleus; site of double-strand break; and ubiquitin ligase complex. Human ortholog(s) of this gene implicated in RIDDLE syndrome. Orthologous to human RNF168 (ring finger protein 168).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64185 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| RIDDLE syndrome | Alliance | RIDDLE syndrome | 611943 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | E3 ubiquitin-protein ligase RNF168 | Zinc finger, C3HC4 RING-type | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M9Q066
|
474 | ||||
|
UniProtKB:Q7T308
|
474 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available