Gene
rnf168
- ID
- ZDB-GENE-030131-6013
- Name
- ring finger protein 168
- Symbol
- rnf168 Nomenclature History
- Previous Names
-
- fi30d02
- wu:fi30d02
- zgc:64185 (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; nucleosome binding activity; and ubiquitin binding activity. Predicted to be involved in several processes, including DNA metabolic process; histone H2A ubiquitination; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within DNA repair and chromatin organization. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus and site of double-strand break. Human ortholog(s) of this gene implicated in RIDDLE syndrome. Orthologous to human RNF168 (ring finger protein 168).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64185 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| RIDDLE syndrome | Alliance | RIDDLE syndrome | 611943 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | E3 ubiquitin-protein ligase RNF168 | RNF168/RNF169 E3 ubiquitin-protein ligase | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M9Q066
|
474 | ||||
|
UniProtKB:Q7T308
|
474 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rnf168-201
(1)
|
Ensembl | 5,619 nt |
Interactions and Pathways
No data available
Plasmids
No data available