Gene

trmt5

ID

ZDB-GENE-030131-5978

Name

tRNA methyltransferase 5

Symbol

trmt5 Nomenclature History

Previous Names

wu:fi28b08

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to enable tRNA (guanine-N1-)-methyltransferase activity and tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity. Predicted to act upstream of or within tRNA methylation. Predicted to be located in mitochondrial matrix. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 26. Orthologous to human TRMT5 (tRNA methyltransferase 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With trmt5 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
combined oxidative phosphorylation deficiency 26	Alliance	Peripheral neuropathy with variable spasticity, exercise intolerance, and developmental delay	616539

Associated With trmt5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR030382	SAM-dependent methyltransferase TRM5/TYW2-type
Family	IPR025792	tRNA (guanine(37)-N(1))-methyltransferase, eukaryotic
Homologous_superfamily	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily