Gene

ptpn11a

ID
ZDB-GENE-030131-5911
Name
protein tyrosine phosphatase non-receptor type 11a
Symbol
ptpn11a Nomenclature History
Previous Names
  • ptpn11
  • fa14b09
  • shp2 (1)
  • wu:fa14b09
  • wu:fi24f03
  • zgc:55388
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Exhibits protein tyrosine phosphatase activity. Involved in several processes, including MAPK cascade; convergent extension involved in axis elongation; and embryonic morphogenesis. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including LEOPARD syndrome (multiple); Noonan syndrome (multiple); juvenile myelomonocytic leukemia; metachondromatosis; and tetralogy of Fallot. Is expressed in blastoderm; blastomere; and head. Orthologous to human PTPN11 (protein tyrosine phosphatase non-receptor type 11).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
13 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ptpn11a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
juvenile myelomonocytic leukemia Alliance Leukemia, juvenile myelomonocytic, somatic 607785
metachondromatosis Alliance Metachondromatosis 156250
Noonan syndrome 1 Alliance Noonan syndrome 1 163950
Noonan syndrome with multiple lentigines 1 Alliance LEOPARD syndrome 1 151100
Associated With ptpn11a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR016130 Protein-tyrosine phosphatase, active site
Domain IPR000242 Tyrosine-specific protein phosphatase, PTPase domain
Domain IPR000387 Tyrosine-specific protein phosphatases domain
Domain IPR000980 SH2 domain
Domain IPR003595 Protein-tyrosine phosphatase, catalytic
Family IPR012152 Protein-tyrosine phosphatase, non-receptor type-6, -11
Homologous_superfamily IPR029021 Protein-tyrosine phosphatase-like
Homologous_superfamily IPR036860 SH2 domain superfamily
Domain Details Per Protein
Protein Length Protein-tyrosine phosphatase, active site Protein-tyrosine phosphatase, catalytic Protein-tyrosine phosphatase-like Protein-tyrosine phosphatase, non-receptor type-6, -11 SH2 domain SH2 domain superfamily Tyrosine-specific protein phosphatase, PTPase domain Tyrosine-specific protein phosphatases domain
UniProtKB:Q7ZW17 594
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations