Gene
prx
- ID
- ZDB-GENE-030131-5790
- Name
- periaxin
- Symbol
- prx Nomenclature History
- Previous Names
-
- fi18g02
- im:7153437
- si:ch211-14c7.3
- wu:fi18g02 (1)
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to be involved in peripheral nervous system myelin maintenance and regulation of RNA splicing. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 3 and Charcot-Marie-Tooth disease type 4F. Orthologous to human PRX (periaxin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa18071 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23378 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23379 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31028 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32221 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36728 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36729 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36730 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43173 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43174 | Allele with one point mutation | Unknown | Unknown | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Charcot-Marie-Tooth disease type 3 | Alliance | Dejerine-Sottas disease | 145900 |
| Charcot-Marie-Tooth disease type 4F | Alliance | Charcot-Marie-Tooth disease, type 4F | 614895 |
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Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-244A7 | ZFIN Curated Data | |
| Encodes | EST | fi18g02 | ||
| Encodes | EST | IMAGE:7153437 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068214970 (1) | 13135 nt | ||
| Genomic | GenBank:CR933839 (2) | 88900 nt | ||
| Polypeptide | RefSeq:XP_068071071 (1) |
- Farnsworth, D.R., Saunders, L.M., Miller, A.C. (2020) A single-cell transcriptome atlas for zebrafish development. Developmental Biology. 459(2):100-108
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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