Gene
dyrk1ab
- ID
- ZDB-GENE-030131-5677
- Name
- dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, b
- Symbol
- dyrk1ab Nomenclature History
- Previous Names
-
- fi12h09
- wu:fi12h09
- wu:fi26g04
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity and transcription coactivator activity. Predicted to be involved in positive regulation of DNA-templated transcription and positive regulation of RNA splicing. Predicted to act upstream of or within protein autophosphorylation. Predicted to be located in nuclear speck. Predicted to be active in nucleus. Is expressed in brain; endothelial cell; eye; heart; and spinal cord. Human ortholog(s) of this gene implicated in Down syndrome; autism spectrum disorder; autosomal dominant intellectual developmental disorder 7; and intellectual disability. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR044131 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain |
| Family | IPR050494 | Serine/threonine and dual-specificity kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine and dual-specificity kinase | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B3P5
|
719 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dyrk1ab-201
(1)
|
Ensembl | 5,881 nt | ||
| mRNA |
dyrk1ab-202
(1)
|
Ensembl | 518 nt | ||
| mRNA |
dyrk1ab-203
(1)
|
Ensembl | 5,861 nt |
Interactions and Pathways
No data available
Plasmids