Gene
rfng
- ID
- ZDB-GENE-030131-5418
- Name
- RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
- Symbol
- rfng Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. Acts upstream of or within brain segmentation; fourth ventricle development; and rhombomere boundary formation. Predicted to be located in Golgi membrane. Is expressed in hindbrain. Orthologous to human RFNG (RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa41933 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Fringe | Fringe-like, glycosyltransferase domain |
|---|---|---|---|---|
| UniProtKB:F1QXC7 | InterPro | 362 | ||
| UniProtKB:Q6KFX9 | InterPro | 362 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-190L11 | ZFIN Curated Data | |
| Encodes | EST | fd16f05 | ||
| Encodes | cDNA | MGC:136694 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:162547 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001001830 (1) | 3762 nt | ||
| Genomic | GenBank:BX548040 (1) | 147855 nt | ||
| Polypeptide | UniProtKB:F1QXC7 (1) | 362 aa |
- Hevia, C.F., Engel-Pizcueta, C., Udina, F., Pujades, C. (2022) The neurogenic fate of the hindbrain boundaries relies on Notch3-dependent asymmetric cell divisions. Cell Reports. 39:110915
- Gordon, P.M., Hamid, F., Makeyev, E.V., Houart, C. (2021) A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons. Nature communications. 12:1918
- Tambalo, M., Mitter, R., Wilkinson, D.G. (2020) A single cell transcriptome atlas of the developing zebrafish hindbrain. Development (Cambridge, England). 147(6):
- Cayuso, J., Xu, Q., Addison, M., Wilkinson, D.G. (2019) Actomyosin regulation by Eph receptor signaling couples boundary cell formation to border sharpness. eLIFE. 8:
- Voltes, A., Hevia, C.F., Engel, C., Dingare, C., Calzolari, S., Terriente, J., Norden, C., Lecaudey, V., Pujades, C. (2019) Yap/Taz-TEAD activity links mechanical cues to progenitor cell behavior during zebrafish hindbrain segmentation. Development (Cambridge, England). 146(14):
- Letelier, J., Terriente, J., Belzunce, I., Voltes, A., Undurraga, C.A., Polvillo, R., Devos, L., Tena, J.J., Maeso, I., Retaux, S., Gomez-Skarmeta, J.L., Martínez-Morales, J.R., Pujades, C. (2018) Evolutionary emergence of the rac3b/rfng/sgca regulatory cluster refined mechanisms for hindbrain boundaries formation.. Proceedings of the National Academy of Sciences of the United States of America. 115(16):E3731-E3740
- Thomas-Jinu, S., Gordon, P.M., Fielding, T., Taylor, R., Smith, B.N., Snowden, V., Blanc, E., Vance, C., Topp, S., Wong, C.H., Bielen, H., Williams, K.L., McCann, E.P., Nicholson, G.A., Pan-Vazquez, A., Fox, A.H., Bond, C.S., Talbot, W.S., Blair, I.P., Shaw, C.E., Houart, C. (2017) Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts Required for Normal Motor Development. Neuron. 94(2):322-336.e5
- Chang, J., Skromne, I., Ho, R.K. (2016) CDX4 and retinoic acid interact to position the hindbrain-spinal cord transition. Developmental Biology. 410(2):178-89
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Terriente, J., Gerety, S.S., Watanabe-Asaka, T., Gonzalez-Quevedo, R., and Wilkinson, D.G. (2012) Signalling from hindbrain boundaries regulates neuronal clustering that patterns neurogenesis. Development (Cambridge, England). 139(16):2978-2987
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