Gene
rnf2
- ID
- ZDB-GENE-030131-5243
- Name
- ring finger protein 2
- Symbol
- rnf2 Nomenclature History
- Previous Names
-
- fa19h05
- ring1b
- wu:fa19h05
- wz4566 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable chromatin binding activity and histone H2AK119 ubiquitin ligase activity. Acts upstream of or within several processes, including embryonic cranial skeleton morphogenesis; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and nervous system development. Predicted to be located in nuclear body. Predicted to be part of MLL1 complex and PRC1 complex. Predicted to be active in cytoplasm and nucleus. Is expressed in gonad; gut; muscle; nervous system; and pectoral fin. Human ortholog(s) of this gene implicated in Luo-Schoch-Yamamoto syndrome. Orthologous to human RNF2 (ring finger protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6909582 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 29 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Luo-Schoch-Yamamoto syndrome | Alliance | Luo-Schoch-Yamamoto syndrome | 619460 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017907 | Zinc finger, RING-type, conserved site |
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR032443 | RAWUL domain |
| Domain | IPR037937 | E3 ubiquitin-protein ligase RING2, RAWUL domain |
| Family | IPR043540 | E3 ubiquitin-protein ligase RING1/RING2 |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
Domain Details Per Protein
| Protein | Length | E3 ubiquitin-protein ligase RING1/RING2 | E3 ubiquitin-protein ligase RING2, RAWUL domain | RAWUL domain | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q803I4
|
336 | ||||||
|
UniProtKB:A0A0H2UKC6
|
338 |
Interactions and Pathways
No data available
Plasmids
No data available