Gene
prpf4
- ID
- ZDB-GENE-030131-5143
- Name
- pre-mRNA splicing tri-snRNP complex factor PRPF4
- Symbol
- prpf4 Nomenclature History
- Previous Names
-
- mg:ab03a02
- zgc:65943
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have U4 snRNA binding activity and U6 snRNA binding activity. Involved in chordate embryonic development; mRNA splicing, via spliceosome; and sensory system development. Predicted to localize to U4/U6 x U5 tri-snRNP complex. Used to study retinitis pigmentosa. Human ortholog(s) of this gene implicated in retinitis pigmentosa 70. Is expressed in brain; eye; posterior lateral line primordium; and spinal cord. Orthologous to human PRPF4 (pre-mRNA processing factor 4).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:65943 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
retinitis pigmentosa 70 | Alliance | Retinitis pigmentosa 70 | 615922 |
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
retinitis pigmentosa | WT + MO1-prpf4 | standard conditions | Linder et al., 2011 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR019775 | WD40 repeat, conserved site |
Domain | IPR014906 | Pre-mRNA processing factor 4 (PRP4)-like |
Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
Homologous_superfamily | IPR036285 | PRP4-like superfamily |
Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
Repeat | IPR001680 | WD40 repeat |
Repeat | IPR020472 | G-protein beta WD-40 repeat |
Domain Details Per Protein
Protein | Length | G-protein beta WD-40 repeat | Pre-mRNA processing factor 4 (PRP4)-like | PRP4-like superfamily | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
---|---|---|---|---|---|---|---|---|
UniProtKB:Q6PH45
|
507 |
Interactions and Pathways
No data available
Plasmids
No data available