Gene
myo1ea
- ID
- ZDB-GENE-030131-5127
- Name
- myosin IEa
- Symbol
- myo1ea Nomenclature History
- Previous Names
-
- myo1e1 (1)
- myo1e
- wu:fc15g04
- wu:fe49h01
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity; actin binding activity; and motor activity. Involved in glomerular filtration and glomerulus development. Predicted to localize to myosin complex. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 6. Is expressed in somite 2 and somite 3. Orthologous to human MYO1E (myosin IE).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Sittaramane et al., 2008
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| focal segmental glomerulosclerosis 6 | Alliance | Glomerulosclerosis, focal segmental, 6 | 614131 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001452 | SH3 domain |
| Domain | IPR010926 | Class I myosin tail homology domain |
| Domain | IPR035507 | Unconventional myosin-Ie/If, SH3 domain |
| Domain | IPR036072 | Class I myosin, motor domain |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Length | Class I myosin, motor domain | Class I myosin tail homology domain | Kinesin motor domain superfamily | P-loop containing nucleoside triphosphate hydrolase | SH3 domain | SH3-like domain superfamily | Unconventional myosin-Ie/If, SH3 domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8N7TD18
|
1106 | |||||||
|
UniProtKB:A0A8M2BG81
|
1116 | |||||||
|
UniProtKB:E7FDV0
|
1117 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
myo1ea-201
(1)
|
Ensembl | 4,565 nt | ||
| mRNA |
myo1ea-202
(1)
|
Ensembl | 817 nt | ||
| mRNA |
myo1ea-204
(1)
|
Ensembl | 2,946 nt | ||
| mRNA |
myo1ea-205
(1)
|
Ensembl | 623 nt | ||
| ncRNA |
myo1ea-002
(1)
|
Ensembl | 612 nt |
Interactions and Pathways
No data available
Plasmids
No data available