Gene
chd4b
- ID
- ZDB-GENE-030131-4532
- Name
- chromodomain helicase DNA binding protein 4b
- Symbol
- chd4b Nomenclature History
- Previous Names
-
- si:ch211-57k11.10
- wu:fb44b12
- wu:fd12d03 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including ATP hydrolysis activity; ATP-dependent chromatin remodeler activity; and histone binding activity. Predicted to be involved in chromatin remodeling. Predicted to be part of NuRD complex. Predicted to be active in chromatin and nucleus. Is expressed in blastomere; central nervous system; hematopoietic multipotent progenitor cell; and telencephalon. Human ortholog(s) of this gene implicated in Sifrim-Hitz-Weiss syndrome; colorectal cancer (multiple); lung cancer (multiple); and lymphoma. Orthologous to human CHD4 (chromodomain helicase DNA binding protein 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Sifrim-Hitz-Weiss syndrome | Alliance | Sifrim-Hitz-Weiss syndrome | 617159 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR002464 | DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site |
| Conserved_site | IPR019786 | Zinc finger, PHD-type, conserved site |
| Domain | IPR000330 | SNF2, N-terminal |
| Domain | IPR000953 | Chromo/chromo shadow domain |
| Domain | IPR001650 | Helicase, C-terminal domain-like |
| Domain | IPR001965 | Zinc finger, PHD-type |
| Domain | IPR009462 | CHD subfamily II, SANT-like domain |
| Domain | IPR009463 | Domain of unknown function DUF1087 |
| Domain | IPR012957 | CHD, C-terminal 2 |
| Domain | IPR012958 | CHD, N-terminal |
| Domain | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| Domain | IPR019787 | Zinc finger, PHD-finger |
| Domain | IPR023780 | Chromo domain |
| Domain | IPR049730 | SNF2/RAD5-like, C-terminal helicase domain |
| Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR016197 | Chromo-like domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR038718 | SNF2-like, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | CHD, C-terminal 2 | CHD, N-terminal | CHD subfamily II, SANT-like domain | Chromo/chromo shadow domain | Chromo domain | Chromo-like domain superfamily | DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site | Domain of unknown function DUF1087 | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | P-loop containing nucleoside triphosphate hydrolase | SNF2-like, N-terminal domain superfamily | SNF2, N-terminal | SNF2/RAD5-like, C-terminal helicase domain | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, PHD-type, conserved site | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PC64
|
1948 | |||||||||||||||||||
|
UniProtKB:A0A8M9PNR4
|
1890 | |||||||||||||||||||
|
UniProtKB:A0A8M9PDP3
|
1949 | |||||||||||||||||||
|
UniProtKB:A0A8N7T760
|
1952 | |||||||||||||||||||
|
UniProtKB:F1RBT2
|
1953 | |||||||||||||||||||
|
UniProtKB:A0A8M9PN35
|
1891 |
Interactions and Pathways
No data available
Plasmids
No data available