Gene
olig2
- ID
- ZDB-GENE-030131-4013
- Name
- oligodendrocyte lineage transcription factor 2
- Symbol
- olig2 Nomenclature History
- Previous Names
-
- wu:fc64g09
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Acts upstream of or within nervous system development and positive regulation of neurogenesis. Predicted to be active in nucleus. Is expressed in several structures, including glioblast; nervous system; neural keel; neural plate; and neural tube. Orthologous to human OLIG2 (oligodendrocyte transcription factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 129 figures from 85 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| is76Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-olig2 | Almeida et al., 2021 | |
| CRISPR2-olig2 | Kamenev et al., 2021 | |
| CRISPR3-olig2 | Kamenev et al., 2021 | |
| MO1-olig2 | N/A | (7) |
| MO2-olig2 | N/A | Filippi et al., 2005 |
| MO3-olig2 | N/A | Yeo et al., 2007 |
| MO4-olig2 | N/A | (4) |
| MO5-olig2 | N/A | Yang et al., 2010 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR032658 | Oligodendrocyte transcription factor 2, basic helix-loop-helix domain |
| Family | IPR050359 | Basic helix-loop-helix transcription factors |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
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Domain Details Per Protein
| Protein | Length | Basic helix-loop-helix transcription factors | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Oligodendrocyte transcription factor 2, basic helix-loop-helix domain |
|---|---|---|---|---|---|
|
UniProtKB:Q8QGI4
|
273 |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(olig2:DsRed2) |
|
| 1 | (90) | |
| Tg(olig2:EGFP) |
|
| 5 | (187) | |
| Tg1(olig2:EGFP) |
|
| 1 | (2) | |
| Tg(olig2:DsRed) |
|
| 1 | Al-Kurbi et al., 2022 | |
| Tg(olig2:Kaede) |
|
| 1 | (7) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-165B19 | ZFIN Curated Data | |
| Encodes | EST | fc64g09 | ||
| Encodes | EST | wz12996 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:65727 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:76800 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_178100 (1) | 1653 nt | ||
| Genomic | GenBank:BX571724 (1) | 174709 nt | ||
| Polypeptide | UniProtKB:Q8QGI4 (1) | 273 aa |
- Itoh, T., Uehara, M., Yura, S., Wang, J.C., Fujii, Y., Nakanishi, A., Shimizu, T., Hibi, M. (2024) Foxp- and Skor-family proteins control differentiation of Purkinje cells from Ptf1a and Neurogenin1-expressing progenitors in zebrafish. Development (Cambridge, England). 151(7):
- Rani, R., Sri, N.S., Medishetti, R., Chatti, K., Sevilimedu, A. (2024) Loss of FMRP affects ovarian development and behaviour through multiple pathways in a zebrafish model of fragile X syndrome. Human molecular genetics. 33(16):1391-1405
- Srivastava, P.P., Bhasin, S., Shankaran, S.S., Roger, C., Ramachandran, R., Minocha, S. (2024) A reproducible method to study traumatic injury-induced zebrafish brain regeneration. Biology methods & protocols. 9:bpae073bpae073
- Azbazdar, Y., Poyraz, Y.K., Ozalp, O., Nazli, D., Ipekgil, D., Cucun, G., Ozhan, G. (2023) High-fat diet feeding triggers a regenerative response in the adult zebrafish brain. Molecular neurobiology. 60(5):2486-2506
- Li, L., Tai, Z., Liu, W., Luo, Y., Wu, Y., Lin, S., Liu, M., Gao, B., Liu, J.X. (2023) Copper overload impairs hematopoietic stem and progenitor cell proliferation via prompting HSF1/SP1 aggregation and the subsequently downregulating FOXM1-Cytoskeleton axis. iScience. 26:106406106406
- Liu, W., Lin, S., Li, L., Tai, Z., Liu, J.X. (2023) Zebrafish ELL-associated factors Eaf1/2 modulate erythropoiesis via regulating gata1a expression and WNT signaling to facilitate hypoxia tolerance. Cell regeneration (London, England). 12:1010
- Miyake, A., Ohmori, T., Murakawa, Y. (2023) Fgf22 and Fgfr2b are required for neurogenesis and gliogenesis in the zebrafish forebrain. Biochemical and Biophysical Research Communications. 681:212217212-217
- O'Brown, N.M., Patel, N.B., Hartmann, U., Klein, A.M., Gu, C., Megason, S.G. (2023) The secreted neuronal signal spock1 promotes blood-brain barrier development. Developmental Cell. 58(17):1534-1547.e6
- Seidl, M.J., Scharre, S., Posset, R., Druck, A.C., Epp, F., Okun, J.G., Dimitrov, B., Hoffmann, G.F., Kölker, S., Zielonka, M. (2023) ASS1 deficiency is associated with impaired neuronal differentiation in zebrafish larvae. Molecular genetics and metabolism. 141:108097108097
- Shi, L., Wang, Z., Li, Y., Song, Z., Yin, W., Hu, B. (2023) Deletion of the chd7 Hinders Oligodendrocyte Progenitor Cell Development and Myelination in Zebrafish. International Journal of Molecular Sciences. 24(17):
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