Gene
tp53bp1
- ID
- ZDB-GENE-030131-3695
- Name
- tumor protein p53 binding protein, 1
- Symbol
- tp53bp1 Nomenclature History
- Previous Names
-
- wu:fc50a09
- wu:fj67d04
- zgc:158452
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable histone binding activity. Predicted to be involved in DNA damage checkpoint signaling and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within DNA damage response. Predicted to be active in nucleus. Orthologous to human TP53BP1 (tumor protein p53 binding protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Yang et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa14524 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21079 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34186 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34187 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34188 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34189 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001357 | BRCT domain |
| Domain | IPR015125 | Tumour suppressor p53-binding protein-1, Tudor domain |
| Domain | IPR047249 | TP53-binding protein 1-like, first BRCT domain |
| Domain | IPR047250 | TP53-binding protein 1-like, second BRCT domain |
| Family | IPR047252 | TP53-binding protein 1-like |
| Homologous_superfamily | IPR014722 | Large ribosomal subunit protein uL2, domain 2 |
| Homologous_superfamily | IPR036420 | BRCT domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | BRCT domain | BRCT domain superfamily | Large ribosomal subunit protein uL2, domain 2 | TP53-binding protein 1-like | TP53-binding protein 1-like, first BRCT domain | TP53-binding protein 1-like, second BRCT domain | Tumour suppressor p53-binding protein-1, Tudor domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z753 | InterPro | 1762 | |||||||
| UniProtKB:A1L1W2 | InterPro | 1709 | |||||||
| UniProtKB:A0A8M6Z7P8 | InterPro | 1499 | |||||||
| UniProtKB:A0A8M6Z1I8 | InterPro | 1642 | |||||||
| UniProtKB:A0A8M6YZZ7 | InterPro | 1754 | |||||||
| UniProtKB:A0A8M9PNZ2 | InterPro | 1636 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tp53bp1-201
(1)
|
Ensembl | 5,546 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contains | SNP | rs3728102 | ZFIN Curated Data | |
| Contains | SNP | rs3728103 | ZFIN Curated Data | |
| Encodes | EST | fc50a09 | ||
| Encodes | EST | fj67d04 | ||
| Encodes | cDNA | MGC:158452 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001080170 (1) | 5330 nt | ||
| Genomic | GenBank:FP236800 (1) | 75115 nt | ||
| Polypeptide | UniProtKB:A0A8M6Z753 (1) | 1762 aa |
- Yang, X., Li, X., Gu, Q., Li, Q., Cui, Z. (2019) Nucleoporin 62-Like Protein is Required for the Development of Pharyngeal Arches through Regulation of Wnt/β-Catenin Signaling and Apoptotic Homeostasis in Zebrafish. Cells. 8(9):
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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