Gene
usp7
- ID
- ZDB-GENE-030131-3656
- Name
- ubiquitin specific peptidase 7 (herpes virus-associated)
- Symbol
- usp7 Nomenclature History
- Previous Names
-
- fc48f04
- wu:fc48f04
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type deubiquitinase activity. Acts upstream of or within cranial skeletal system development. Predicted to be active in cytosol and nucleus. Orthologous to human USP7 (ubiquitin specific peptidase 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7155505 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la010554Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la024068Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa20019 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-usp7 | LaCoursiere et al., 2024 | |
| CRISPR2-usp7 | LaCoursiere et al., 2024 | |
| MO1-usp7 | N/A | (2) |
| MO2-usp7 | N/A | Zhou et al., 2015 |
| TALEN1-usp7 | Thomas et al., 2014 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Hao-Fountain syndrome | 616863 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018200 | Ubiquitin specific protease, conserved site |
| Domain | IPR001394 | Peptidase C19, ubiquitin carboxyl-terminal hydrolase |
| Domain | IPR002083 | MATH/TRAF domain |
| Domain | IPR024729 | Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain |
| Domain | IPR028889 | Ubiquitin specific protease domain |
| Domain | IPR029346 | Ubiquitin carboxyl-terminal hydrolase, C-terminal |
| Family | IPR050164 | Ubiquitin carboxyl-terminal hydrolases |
| Homologous_superfamily | IPR008974 | TRAF-like |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | MATH/TRAF domain | Papain-like cysteine peptidase superfamily | Peptidase C19, ubiquitin carboxyl-terminal hydrolase | TRAF-like | Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain | Ubiquitin carboxyl-terminal hydrolase, C-terminal | Ubiquitin carboxyl-terminal hydrolases | Ubiquitin specific protease, conserved site | Ubiquitin specific protease domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q474 | InterPro | 1086 | |||||||||
| UniProtKB:A0A8M3AQW7 | InterPro | 1123 | |||||||||
| UniProtKB:A0A8M3B0Y8 | InterPro | 1096 | |||||||||
| UniProtKB:A0A8M3B8A7 | InterPro | 1130 | |||||||||
| UniProtKB:I3ISS5 | InterPro | 1103 | |||||||||
| UniProtKB:F1QUS9 | InterPro | 1110 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-157C3 | ||
| Contained in | BAC | CH211-158B12 | ||
| Encodes | EST | fc48f04 | ||
| Encodes | EST | IMAGE:7155505 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005163957 (1) | 5530 nt | ||
| Genomic | GenBank:CR394572 (1) | 147156 nt | ||
| Polypeptide | UniProtKB:A0A8M3B8A7 (1) | 1130 aa |
- LaCoursiere, C.M., Ullmann, J.F.P., Koh, H.Y., Turner, L., Baker, C.M., Robens, B., Shao, W., Rotenberg, A., McGraw, C.M., Poduri, A.H. (2024) Zebrafish models of candidate human epilepsy-associated genes provide evidence of hyperexcitability. iScience. 27:110172110172
- Loontiens, S., Vanhauwaert, S., Depestel, L., Dewyn, G., Van Loocke, W., Moore, F.E., Garcia, E.G., Batchelor, L., Borga, C., Squiban, B., Malone-Perez, M., Volders, P.J., Olexiouk, V., Van Vlierberghe, P., Langenau, D.M., Frazer, J.K., Durinck, K., Speleman, F. (2020) A novel TLX1-driven T-ALL zebrafish model: comparative genomic analysis with other leukemia models. Leukemia. 34(12):3398-3403
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Tse, W.K.F. (2017) Importance of deubiquitinases in zebrafish craniofacial development. Biochemical and Biophysical Research Communications. 487(4):813-819
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Zhou, Z., Yao, X., Li, S., Xiong, Y., Dong, X., Zhao, Y., Jiang, J., Zhang, Q. (2015) Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling. Developmental Cell. 34:587258-72
- Thomas, H.R., Percival, S.M., Yoder, B.K., Parant, J.M. (2014) High-Throughput Genome Editing and Phenotyping Facilitated by High Resolution Melting Curve Analysis. PLoS One. 9:e114632
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Tse, W.K., Eisenhaber, B., Ho, S.H., Ng, Q., Eisenhaber, F., and Jiang, Y.J. (2009) Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. BMC Genomics. 10:637
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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