Gene

cyb5r3

ID

ZDB-GENE-030131-3281

Name

cytochrome b5 reductase 3

Symbol

cyb5r3 Nomenclature History

Previous Names

fc32h03
wu:fc32h03
zgc:77071 (1)

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Enables NADH dehydrogenase activity. Predicted to act upstream of or within cholesterol biosynthetic process. Predicted to be located in endoplasmic reticulum membrane and mitochondrial outer membrane. Predicted to be active in mitochondrion. Is expressed in yolk syncytial layer. Human ortholog(s) of this gene implicated in breast cancer and methemoglobinemia. Orthologous to human CYB5R3 (cytochrome b5 reductase 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2005

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu1002 (4 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cyb5r3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Methemoglobinemia, type I	250800
		Methemoglobinemia, type II	250800

Associated With cyb5r3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001433	Oxidoreductase FAD/NAD(P)-binding
Domain	IPR001709	Flavoprotein pyridine nucleotide cytochrome reductase
Domain	IPR008333	Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain
Domain	IPR017927	FAD-binding domain, ferredoxin reductase-type
Family	IPR001834	NADH:cytochrome b5 reductase-like
Homologous_superfamily	IPR017938	Riboflavin synthase-like beta-barrel
Homologous_superfamily	IPR039261	Ferredoxin-NADP reductase (FNR), nucleotide-binding domain