Gene

cpt1ab

ID

ZDB-GENE-030131-3250

Name

carnitine palmitoyltransferase 1Ab (liver)

Symbol

cpt1ab Nomenclature History

Previous Names

fc31g06
si:ch211-236l14.3
wu:fc31g06 (1)

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have carnitine O-palmitoyltransferase activity. Involved in lymph vessel development and regulation of fatty acid beta-oxidation. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in carnitine palmitoyltransferase I deficiency and lipid metabolism disorder. Orthologous to human CPT1A (carnitine palmitoyltransferase 1A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Zecchin et al., 2018
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cpt1ab Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
carnitine palmitoyltransferase I deficiency	Alliance	CPT deficiency, hepatic, type IA	255120

Associated With cpt1ab Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR032476	Carnitine O-palmitoyltransferase, N-terminal
Domain	IPR039551	Choline/carnitine acyltransferase domain
Family	IPR000542	Acyltransferase ChoActase/COT/CPT
Homologous_superfamily	IPR023213	Chloramphenicol acetyltransferase-like domain superfamily
Homologous_superfamily	IPR042231	Choline/Carnitine o-acyltransferase, domain 2

Domain Details Per Protein

Protein	Length	Acyltransferase ChoActase/COT/CPT	Carnitine O-palmitoyltransferase, N-terminal	Chloramphenicol acetyltransferase-like domain superfamily	Choline/carnitine acyltransferase domain	Choline/Carnitine o-acyltransferase, domain 2
UniProtKB:A0A8M9PEG9 InterPro	775
UniProtKB:A0A8M9PNB1 InterPro	428
UniProtKB:A0A8M9PR97 InterPro	774
UniProtKB:K7DY29 InterPro	774
UniProtKB:A0A8M9PXF3 InterPro	428
UniProtKB:E9QI17 InterPro	775

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	cpt1ab-201 (1) Ensembl	Ensembl		5,195 nt	Select Tool ZFIN BLAST
mRNA	cpt1ab-202 (1) Ensembl	Ensembl		3,570 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations