Gene
hmga2
- ID
- ZDB-GENE-030131-3148
- Name
- high mobility group AT-hook 2
- Symbol
- hmga2 Nomenclature History
- Previous Names
-
- wu:fc27f12
- wu:fc28f02
- wu:fc57d12
- zgc:77719
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable transcription coregulator activity. Acts upstream of or within sprouting angiogenesis. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in several structures, including blood vessel; head; nervous system; pectoral fin bud; and pronephric duct. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; leiomyoma; lipoma; and ovarian cancer. Orthologous to human HMGA2 (high mobility group AT-hook 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77719 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Wang et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ct29aGt | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-hmga2 | N/A | (2) |
| MO2-hmga2 | N/A | Huang et al., 2013 |
| MO3-hmga2 | N/A | O'Hare et al., 2016 |
| MO4-hmga2 | N/A | Wang et al., 2021 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Silver-Russell syndrome 5 | 618908 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | AT hook, DNA-binding motif | High mobility group protein HMGA | HMG-I/HMG-Y, DNA-binding, conserved site |
|---|---|---|---|---|
|
UniProtKB:Q6P038
|
110 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-6A5 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-150I15 | ZFIN Curated Data | |
| Encodes | EST | fc27f12 | ZFIN Curated Data | |
| Encodes | EST | fc28f02 | ||
| Encodes | EST | fc57d12 | ||
| Encodes | cDNA | MGC:77719 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212680 (1) | 1409 nt | ||
| Genomic | GenBank:BX119963 (1) | 229125 nt | ||
| Polypeptide | UniProtKB:Q6P038 (1) | 110 aa |
- Song, Y., Chen, W., Zhu, B., Ge, W. (2022) Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary. Frontiers in cell and developmental biology. 9:750888
- Sinclair, J.W., Hoying, D.R., Bresciani, E., Nogare, D.D., Needle, C.D., Berger, A., Wu, W., Bishop, K., Elkahloun, A.G., Chitnis, A., Liu, P., Burgess, S.M. (2021) The Warburg effect is necessary to promote glycosylation in the blastema during zebrafish tail regeneration. NPJ Regenerative medicine. 6:55
- Wang, J., Chen, Y., Zeng, Z., Feng, R., Wang, Q., Zhang, Q., Sun, K., Chen, A.F., Lu, Y., Yu, Y. (2021) HMGA2 contributes to vascular development and sprouting angiogenesis by promoting IGFBP2 production. Experimental cell research. 408(1):112831
- Shi, X., Huang, T., Wang, J., Liang, Y., Gu, C., Xu, Y., Sun, J., Lu, Y., Sun, K., Chen, S., Yu, Y. (2018) Next-generation sequencing identifies novel genes with rare variants in total anomalous pulmonary venous connection. EBioMedicine. 38:217-227
- Li, C., Chen, Q., Zhang, X., Snyder, S.A., Gong, Z., Lam, S.H. (2017) An integrated approach with the zebrafish model for biomonitoring of municipal wastewater effluent and receiving waters. Water research. 131:33-44
- O'Hare, E.A., Yerges-Armstrong, L.M., Perry, J.A., Shuldiner, A.R., Zaghloul, N.A. (2016) Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. Molecular endocrinology (Baltimore, Md.). 30(4):429-45
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Ju Shin, Y., Kyun Park, S., Jung Jung, Y., Na Kim, Y., Sung Kim, K., Kyu Park, O., Kwon, S.H., Ho Jeon, S., Trinh, l.e. .A., Fraser, S.E., Kee, Y., Joon Hwang, B. (2015) Nanobody-targeted E3-ubiquitin ligase complex degrades nuclear proteins. Scientific Reports. 5:14269
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- Moussavi Nik, S.H., Newman, M., and Lardelli, M. (2011) The response of HMGA1 to changes in oxygen availability is evolutionarily conserved. Experimental cell research. 317(11):1503-1512
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