ZFIN ID: ZDB-GENE-030131-2921
Gene Name: dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
Gene Symbol: dlat
Previous Names: noa, fc86g11, fj57d06, no optokinetic nystagmus a, no optokinetic response b (1), nrb (1), wu:fc14f10 (1), wu:fc21f08 (1), wu:fc86g11 (1), wu:fj57d06 (1)
Location: Chr: 21   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 3 figures from Baxendale et al., 2009
Wild-type Stages, Structures: Segmentation:5-9 somites (11.66h-14.0h) to Larval:Day 4 (96.0h-120.0h)
  adaxial cell, ectoderm, eye, head (all 10) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 4 genotypes
Alleles: a13, m631
PHENOTYPE
Data: 2 figures from Phenotype Annotation (1994-2006)
Observed in: eye, musculoskeletal movement, pigment cell, sensory system (all 5) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Pyruvate dehydrogenase E2 deficiency 245348
GENE ONTOLOGY
Ontology GO Term
Biological Process acetyl-CoA biosynthetic process from pyruvate (more)
Cellular Component mitochondrial matrix (more)
Molecular Function CONTRIBUTES_TO pyruvate dehydrogenase activity (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000089 (1)
  • InterPro:IPR001078 (1)
  • InterPro:IPR003016 (1)
  • InterPro:IPR004167 (1)
  • InterPro:IPR006257 (1)
  • InterPro:IPR011053 (1)
  • InterPro:IPR023213 (1)
  • PROSITE:PS00189 (1)
  • PROSITE:PS50968 (1)
  • Pfam:PF00198 (1)
  • Pfam:PF00364 (1)
  • Pfam:PF02817 (1)
  • EC:2.3.1.12 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA dlat-001 (1) 3382
     Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dlat No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    dlat Contained in: [BAC] CH73-285B21 (1) (order this), DKEYP-14B8 (1)
    dlat Contains: [SNP] rs3729104 (1), rs3729105 (1)
    dlat Encodes: [EST] fc14f10, fc21f08, fc86g11, fj57d06
    [cDNA] MGC:194568 (1) (order this), MGC:194582 (1) (order this)
    dlat Has Artifact: [cDNA] MGC:111854 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_212667 (1) 1959 bp
    Genomic GenBank:BX296544 (1) 168838 bp
    Select Tool
    Polypeptide UniProtKB:B3DIV6 (1) 652 aa
    Sequence Clusters UniGene:31625 (1)
    Sequence Information (all 22)
    OTHER dlat GENE PAGES
  • Gene:324201 (1)
  • VEGA:OTTDARG00000034756 (1)
  • Ensembl(Zv9):ENSDARG00000015918 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish dlat 21  
    Human DLAT 11 (11q23.1)
  • OMIM:608770
  • Gene:1737
  • Orthology Details
    CITATIONS (26)