Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-030131-2921
Gene Name: dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
Gene Symbol: dlat
Previous Names: noa, fc86g11, fj57d06, no optokinetic nystagmus a, no optokinetic response b (1), nrb (1), wu:fc14f10 (1), wu:fc21f08 (1), wu:fc86g11 (1), wu:fj57d06 (1)
Location: Chr: 21   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 3 figures from Baxendale et al., 2009
Wild-type Stages, Structures: Segmentation:5-9 somites (11.66h-14.0h) to Larval:Day 4 (96.0h-120.0h)
  adaxial cell, ectoderm, eye, head (all 10) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 4 genotypes
Alleles: a13, m631
PHENOTYPE
Data: 2 figures from Phenotype Annotation (1994-2006)
Observed in: eye, musculoskeletal movement, pigment cell, sensory system (all 5) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Pyruvate dehydrogenase E2 deficiency 245348
GENE ONTOLOGY
Ontology GO Term
Biological Process acetyl-CoA biosynthetic process from pyruvate (more)
Cellular Component mitochondrial matrix (more)
Molecular Function CONTRIBUTES_TO pyruvate dehydrogenase activity (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000089 (1)
  • InterPro:IPR001078 (1)
  • InterPro:IPR003016 (1)
  • InterPro:IPR004167 (1)
  • InterPro:IPR006257 (1)
  • InterPro:IPR011053 (1)
  • InterPro:IPR023213 (1)
  • PROSITE:PS00189 (1)
  • PROSITE:PS50968 (1)
  • Pfam:PF00198 (1)
  • Pfam:PF00364 (1)
  • Pfam:PF02817 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA dlat-001 (1) 2072
     Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM dlat No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    dlat Contained in: [BAC] CH73-285B21 (1) (order this), DKEYP-14B8 (1)
    dlat Contains: [SNP] rs3729104 (1), rs3729105 (1)
    dlat Encodes: [EST] fc14f10, fc21f08, fc86g11, fj57d06
    [cDNA] MGC:194568 (1) (order this), MGC:194582 (1) (order this)
    dlat Has Artifact: [cDNA] MGC:111854 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_212667 (1) 1959 bp
    Genomic GenBank:BX296544 (1) 168838 bp
    Select Tool
    Polypeptide UniProtKB:B3DIV6 (1) 652 aa
    Sequence Clusters UniGene:31625 (1)
    Sequence Information (all 22)
    OTHER dlat GENE PAGES
  • Gene:324201 (1)
  • VEGA:OTTDARG00000034756 (1)
  • Ensembl(Zv9):ENSDARG00000015918 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish dlat 21  
    Human DLAT 11 (11q23.1)
  • OMIM:608770
  • Gene:1737
  • Orthology Details
    CITATIONS (25)