ZFIN ID: ZDB-GENE-030131-2921
Gene Name: dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
Gene Symbol: dlat

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Previous Names: fc86g11, fj57d06, no optokinetic nystagmus a, no optokinetic response b (1), noa, nrb (1), wu:fc14f10 (1), wu:fc21f08 (1), wu:fc86g11 (1), wu:fj57d06 (1)

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(Including Attributions)
Location: Chr: 21 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 3 figures from Baxendale et al., 2009
Wild-type Stages, Structures: Segmentation:5-9 somites (11.66h-14.0h) to Larval:Day 4 (96.0h-120.0h)
  adaxial cell, ectoderm, eye, head (all 10) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a13 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m631 Point Mutation Unknown Missense ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37305 Point Mutation Unknown Splice Site ENU
    sa37306 Point Mutation Unknown Splice Site ENU
    PHENOTYPE
    Data: 3 figures from 2 publications
    Observed in: eye, musculoskeletal movement, pigment cell, pigmentation (all 7) expand
    DISEASE ASSOCIATED WITH dlat HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    pyruvate decarboxylase deficiency Pyruvate dehydrogenase E2 deficiency 245348
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process acetyl-CoA biosynthetic process from pyruvate (more)
    Cellular Component mitochondrial matrix (more)
    Molecular Function CONTRIBUTES_TO pyruvate dehydrogenase activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000089 (1)
  • InterPro:IPR001078 (1)
  • InterPro:IPR003016 (1)
  • InterPro:IPR004167 (1)
  • InterPro:IPR006257 (1)
  • InterPro:IPR011053 (1)
  • InterPro:IPR023213 (1)
  • PROSITE:PS00189 (1)
  • PROSITE:PS50968 (1)
  • Pfam:PF00198 (1)
  • Pfam:PF00364 (1)
  • Pfam:PF02817 (1)
  • EC:2.3.1.12 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA dlat-001 (1) 3382
     Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM dlat No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    dlatContained in: [BAC] CH73-285B21 (1) (order this), DKEYP-14B8 (1)
    dlatContains: [SNP] rs3729104 (1), rs3729105 (1)
    dlatEncodes: [EST] fc14f10, fc21f08, fc86g11, fj57d06
    [cDNA] MGC:194568 (1) (order this), MGC:194582 (1) (order this)
    dlatHas Artifact: [cDNA] MGC:111854 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_212667 (1) 1959bp
    Genomic GenBank:BX296544 (1) 168838bp
    Select Tool
    Polypeptide UniProtKB:B3DIV6 (1) 652aa
    Sequence Clusters UniGene:31625 (1)
    Sequence Information (all 22)
    OTHER dlat GENE PAGES
  • Gene:324201 (1)
  • VEGA:OTTDARG00000034756 (1)
  • Ensembl(GRCz10):ENSDARG00000015918 (1)
  • ORTHOLOGY for dlat (Chr: 21)
    Species Symbol Chromosome Accession # Evidence
    Human DLAT 11
  • Gene:1737
  • OMIM:608770
  • HGNC:2896
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (28)