Gene
stag2b
- ID
- ZDB-GENE-030131-2785
- Name
- STAG2 cohesin complex component b
- Symbol
- stag2b Nomenclature History
- Previous Names
-
- fc17g12
- wu:fc17g12 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable chromatin binding activity. Acts upstream of or within regulation of hematopoietic progenitor cell differentiation and regulation of vasculogenesis. Predicted to be part of cohesin complex. Predicted to be active in chromatin and nucleus. Is expressed in head and trunk. Human ortholog(s) of this gene implicated in Mullegama-Klein-Martinez syndrome and holoprosencephaly. Orthologous to human STAG2 (stromal antigen 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Ketharnathan et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Holoprosencephaly 13, X-linked | Alliance | Holoprosencephaly 13, X-linked | 301043 |
| Mullegama-Klein-Martinez syndrome | Alliance | Mullegama-Klein-Martinez syndrome | 301022 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Armadillo-type fold | Cohesin subunit Scc3/SA | STAG | Stromalin conservative domain |
|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IZR5
|
1276 | ||||
|
UniProtKB:E7FE97
|
1269 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
stag2b-201
(1)
|
Ensembl | 3,810 nt | ||
| mRNA |
stag2b-202
(1)
|
Ensembl | 1,055 nt | ||
| mRNA |
stag2b-203
(1)
|
Ensembl | 748 nt | ||
| mRNA |
stag2b-204
(1)
|
Ensembl | 6,646 nt | ||
| mRNA |
stag2b-206
(1)
|
Ensembl | 3,831 nt | ||
| ncRNA |
stag2b-003
(1)
|
Ensembl | 705 nt |
Interactions and Pathways
No data available
Plasmids
No data available