Gene
nsd2
- ID
- ZDB-GENE-030131-2581
- Name
- nuclear receptor binding SET domain protein 2
- Symbol
- nsd2 Nomenclature History
- Previous Names
-
- fc12c04
- si:rp71-77d7.2
- whsc1
- wu:fc12c04
- wu:fi20c01
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Enables histone H3K36 methyltransferase activity. Acts upstream of or within cartilage development and embryonic skeletal system development. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including fin; immature eye; nervous system; neural plate; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human NSD2 (nuclear receptor binding SET domain protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7158283 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Rauch-Steindl syndrome | 619695 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019786 | Zinc finger, PHD-type, conserved site |
| Domain | IPR000313 | PWWP domain |
| Domain | IPR001214 | SET domain |
| Domain | IPR001965 | Zinc finger, PHD-type |
| Domain | IPR003616 | Post-SET domain |
| Domain | IPR006560 | AWS domain |
| Domain | IPR019787 | Zinc finger, PHD-finger |
| Domain | IPR041306 | NSD, Cys-His rich domain |
| Domain | IPR047435 | Nuclear SET domain-containing protein 2, second PWWP domain |
| Domain | IPR047437 | Nuclear SET domain-containing protein 2, SET domain |
| Domain | IPR055197 | Histone-lysine N-methyltransferase NSD-like, variant PHD zinc finger |
| Domain | IPR055198 | Histone-lysine N-methyltransferase NSD-like, PHD zinc finger |
| Family | IPR050777 | SET2 Histone-Lysine N-Methyltransferase |
| Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR046341 | SET domain superfamily |
Domain Details Per Protein
| Protein | Length | AWS domain | Histone-lysine N-methyltransferase NSD-like, PHD zinc finger | Histone-lysine N-methyltransferase NSD-like, variant PHD zinc finger | NSD, Cys-His rich domain | Nuclear SET domain-containing protein 2, second PWWP domain | Nuclear SET domain-containing protein 2, SET domain | Post-SET domain | PWWP domain | SET2 Histone-Lysine N-Methyltransferase | SET domain | SET domain superfamily | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, PHD-type, conserved site | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B8JIA4
|
1461 |
Interactions and Pathways
No data available
Plasmids
No data available