Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-030131-2581
Gene Name: Wolf-Hirschhorn syndrome candidate 1
Gene Symbol: whsc1
Previous Names: fc12c04, si:rp71-77d7.2, wu:fc12c04, wu:fi20c01
Location: Chr: 13   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 9 figures from 3 publications
Directly Submitted Expression Data: 6 figures (20 images) from Thisse et al., 2004 [IMAGE:7158283]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  brain, central nervous system, eye, fin (all 16) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Knockdown reagents: CRISPR1-whsc1 (1), MO1-whsc1 (1), MO2-whsc1 (1)
PHENOTYPE
Data: 4 figures from Yamada-Okabe et al., 2010
Observed in: bone development, brain, cartilage element, ceratobranchial cartilage (all 10) expand
GENE ONTOLOGY
Ontology GO Term
Biological Process cartilage development (more)
Cellular Component nucleus (more)
Molecular Function histone-lysine N-methyltransferase activity (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000313 (1)
  • InterPro:IPR001214 (1)
  • InterPro:IPR001841 (1)
  • InterPro:IPR001965 (1)
  • InterPro:IPR003616 (1)
  • InterPro:IPR006560 (1)
  • InterPro:IPR011011 (1)
  • InterPro:IPR013083 (1)
  • InterPro:IPR019786 (1)
  • InterPro:IPR019787 (1)
  • PROSITE:PS01359 (1)
  • PROSITE:PS50016 (1)
  • PROSITE:PS50280 (1)
  • PROSITE:PS50812 (1)
  • PROSITE:PS50868 (1)
  • PROSITE:PS51215 (1)
  • Pfam:PF00628 (1)
  • Pfam:PF00855 (1)
  • Pfam:PF00856 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA whsc1-001 (1) 5357
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM whsc1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    whsc1 Contained in: [BAC] CH211-195N12 (1) (order this), CH211-233A24 (1) (order this)
    whsc1 Encodes: [EST] fc12c04, fi20c01, IMAGE:7158283 (1) (order this)
    [cDNA] MGC:198423 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001082551 (1) 5347 bp
    Genomic GenBank:CR556722 (1) 205873 bp Blast at MegaBLAST
    Polypeptide UniProtKB:B7ZVT1 (1) 1461 aa
    Sequence Clusters UniGene:78031 (1)
    Sequence Information (all 44)
    OTHER whsc1 GENE PAGES
  • Gene:100000709 (1)
  • VEGA:OTTDARG00000023818 (1)
  • Ensembl(Zv9):ENSDARG00000026225 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish whsc1 13  
    Human WHSC1 4 (4p16.3)
  • OMIM:602952
  • Gene:7468
  • Mouse Whsc1 5 ( 17.83 cM)
  • MGI:1276574
  • Gene:107823
  • Orthology Details
    CITATIONS (17)