Gene
tfcp2
- ID
- ZDB-GENE-030131-2523
- Name
- transcription factor CP2
- Symbol
- tfcp2 Nomenclature History
- Previous Names
-
- fc10e04
- si:ch211-210c8.8
- wu:fc10e04 (1)
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in brain. Orthologous to human TFCP2 (transcription factor CP2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Ahi et al., 2021
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa9853 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17044 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa18190 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19332 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa29979 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CP2 transcription factor | SAM domain | Sterile alpha motif/pointed domain superfamily | Transcription factor CP2-like | Transcription factor CP2, SAM domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1Q1I0 | InterPro | 498 | |||||
| UniProtKB:A0A8M2B984 | InterPro | 510 | |||||
| UniProtKB:A0A8M6YW24 | InterPro | 496 | |||||
| UniProtKB:E7EYC1 | InterPro | 512 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-210C8 | ZFIN Curated Data | |
| Encodes | EST | fc10e04 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005162354 (1) | 3142 nt | ||
| Genomic | GenBank:CR354542 (2) | 157560 nt | ||
| Polypeptide | UniProtKB:E7EYC1 (1) | 512 aa |
- Ahi, E.P., Tsakoumis, E., Brunel, M., Schmitz, M. (2021) Transcriptional study reveals a potential leptin-dependent gene regulatory network in zebrafish brain. Fish physiology and biochemistry. 47(4):1283-1298
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Jänicke, M., Renisch, B., and Hammerschmidt, M. (2010) Zebrafish grainyhead-like1 is a common marker of different non-keratinocyte epidermal cell lineages, which segregate from each other in a Foxi3-dependent manner. The International journal of developmental biology. 54(5):837-850
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