Gene
gpr182
- ID
- ZDB-GENE-030131-2361
- Name
- G protein-coupled receptor 182
- Symbol
- gpr182 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Enables G protein-coupled receptor activity. Acts upstream of or within G protein-coupled receptor signaling pathway and negative regulation of hematopoietic stem cell differentiation. Predicted to be located in plasma membrane. Is expressed in several structures, including blood; endothelial cell; lateral mesoderm; retina; and vasculature. Orthologous to human GPR182 (G protein-coupled receptor 182).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6893998 (18 images)
- IMAGE:7159770 (14 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| bns289 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ioz121 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| sa1354 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12195 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37767 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| um72 | Allele with one deletion | Unknown | Frameshift, Premature Stop | zinc finger nuclease | |
| um73 | Allele with one deletion | Unknown | Frameshift, Premature Stop | zinc finger nuclease |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-gpr182 | Kwon et al., 2020 | |
| CRISPR2-gpr182 | Xia et al., 2021 | |
| MO1-gpr182 | N/A | Xia et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | GPCR, rhodopsin-like, 7TM | G-protein coupled estrogen receptor 1-like | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|
|
UniProtKB:Q535D9
|
358 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gpr182-201
(1)
|
Ensembl | 1,481 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | RP71-49B22 | ||
| Encodes | EST | fc05g10 | ||
| Encodes | EST | IMAGE:6893998 | Thisse et al., 2004 | |
| Encodes | EST | IMAGE:7159770 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:153832 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020478 (1) | 1452 nt | ||
| Genomic | GenBank:BX321896 (1) | 165985 nt | ||
| Polypeptide | UniProtKB:Q535D9 (1) | 358 aa |
- Tsaryk, R., Yucel, N., Leonard, E.V., Diaz, N., Bondareva, O., Odenthal-Schnittler, M., Arany, Z., Vaquerizas, J.M., Schnittler, H., Siekmann, A.F. (2022) Shear stress switches the association of endothelial enhancers from ETV/ETS to KLF transcription factor binding sites. Scientific Reports. 12:4795
- Xia, J., Kang, Z., Xue, Y., Ding, Y., Gao, S., Zhang, Y., Lv, P., Wang, X., Ma, D., Wang, L., Han, J.J., Liu, F. (2021) A single-cell resolution developmental atlas of hematopoietic stem and progenitor cell expansion in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 118(14):
- Gillotay, P., Shankar, M., Haerlingen, B., Sema Elif, E., Pozo-Morales, M., Garteizgogeascoa, I., Reinhardt, S., Kränkel, A., Bläsche, J., Petzold, A., Ninov, N., Kesavan, G., Lange, C., Brand, M., Lefort, A., Libert, F., Detours, V., Costagliola, S., Singh, S.P. (2020) Single-cell transcriptome analysis reveals thyrocyte diversity in the zebrafish thyroid gland. EMBO reports. 21(12):e50612
- Kwon, H.B., Mackie, D.I., Bonnavion, R., Mercier, A.L., Helker, C.S.M., Son, T., Guenter, S., Serafin, D.S., Kim, K.W., Offermanns, S., Caron, K.M., Stainier, D.Y.R. (2020) The Orphan G-Protein Coupled Receptor 182 Is a Negative Regulator of Definitive Hematopoiesis through Leukotriene B4 Signaling. ACS pharmacology & translational science. 3:676-689
- Chestnut, B., Sumanas, S. (2019) Zebrafish etv2 knock-in line labels vascular endothelial and blood progenitor cells. Developmental Dynamics : an official publication of the American Association of Anatomists. 249(2):245-261
- Moore, C., Richens, J.L., Hough, Y., Ucanok, D., Malla, S., Sang, F., Chen, Y., Elworthy, S., Wilkinson, R.N., Gering, M. (2018) Gfi1aa and Gfi1b set the pace for primitive erythroblast differentiation from hemangioblasts in the zebrafish embryo. Blood advances. 2:2589-2606
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kok, F.O., Shin, M., Ni, C., Gupta, A., Grosse, A.S., van Impel, A., Kirchmaier, B.C., Peterson-Maduro, J., Kourkoulis, G., Male, I., DeSantis, D.F., Sheppard-Tindell, S., Ebarasi, L., Betsholtz, C., Schulte-Merker, S., Wolfe, S.A., Lawson, N.D. (2015) Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish. Developmental Cell. 32(1):97-108
- Li, L., Chen, D., Li, J., Wang, X., Wang, N., Xu, C., and Wang, Q.K. (2014) Aggf1 acts at the top of the genetic regulatory hierarchy in specification of hemangioblasts in zebrafish. Blood. 123(4):501-8
- Alghisi, E., Distel, M., Malagola, M., Anelli, V., Santoriello, C., Herwig, L., Krudewig, A., Henkel, C.V., Russo, D., and Mione, M.C. (2013) Targeting oncogene expression to endothelial cells induces proliferation of the myelo-erythroid lineage by repressing the notch pathway. Leukemia. 24(6):943-53
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