Gene
ace
- ID
- ZDB-GENE-030131-1826
- Name
- angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
- Symbol
- ace Nomenclature History
- Previous Names
-
- fb81h03
- si:ch211-124e16.1
- wu:fb81h03 (1)
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable metallopeptidase activity and peptidyl-dipeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adaxial cell; digestive system; eye; heart; and kidney. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting enzyme).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Renal tubular dysgenesis | 267430 | ||
| [Angiotensin I-converting enzyme, benign serum increase] | |||
| {Microvascular complications of diabetes 3} | 612624 | ||
| {Myocardial infarction, susceptibility to} | |||
| {SARS, progression of} | |||
| {Stroke, hemorrhagic} | 614519 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR001548 | Peptidase M2, peptidyl-dipeptidase A |
Domain Details Per Protein
| Protein | Length | Peptidase M2, peptidyl-dipeptidase A |
|---|---|---|
|
UniProtKB:E7FFA5
|
1324 |
Interactions and Pathways
No data available
Plasmids
No data available