Gene

ddx3xa

ID

ZDB-GENE-030131-1565

Name

DEAD-box helicase 3 X-linked a

Symbol

ddx3xa Nomenclature History

Previous Names

ddx3
ddx3a
fb74g09
wu:fb74g09
zgc:158804

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to have RNA binding activity and RNA helicase activity. Predicted to be involved in cell differentiation and gamete generation. Predicted to localize to P granule and nucleus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Orthologous to human DDX3X (DEAD-box helicase 3 X-linked).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Mueller et al., 2010

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ddx3xa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Intellectual developmental disorder, X-linked syndromic, Snijders Blok type	300958

Associated With ddx3xa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000629	ATP-dependent RNA helicase DEAD-box, conserved site
Domain	IPR001650	Helicase, C-terminal domain-like
Domain	IPR011545	DEAD/DEAH box helicase domain
Domain	IPR014001	Helicase superfamily 1/2, ATP-binding domain
Domain	IPR014014	RNA helicase, DEAD-box type, Q motif
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	ATP-dependent RNA helicase DEAD-box, conserved site	DEAD/DEAH box helicase domain	Helicase, C-terminal domain-like	Helicase superfamily 1/2, ATP-binding domain	P-loop containing nucleoside triphosphate hydrolase	RNA helicase, DEAD-box type, Q motif
UniProtKB:A0A8M9QAW2 InterPro	792
UniProtKB:A0A8M6Z8G4 InterPro	728
UniProtKB:A0A8M9QFI7 InterPro	841
UniProtKB:A0A8M9QAW0 InterPro	825
UniProtKB:A0A8M2BF54 InterPro	693
UniProtKB:B0S6P6 InterPro	709
UniProtKB:A0A8M9QJS4 InterPro	784
UniProtKB:A0A8M6Z099 InterPro	728
UniProtKB:A0A8M9Q4N5 InterPro	840
UniProtKB:A0A8M9QFJ0 InterPro	813
UniProtKB:A0A8M9QFJ5 InterPro	713
UniProtKB:A0A8M3B2Q5 InterPro	708
UniProtKB:A0A8M9QJR9 InterPro	821
UniProtKB:A0A8M9PS93 InterPro	840
UniProtKB:A0A8M9Q4N8 InterPro	812
UniProtKB:A0A8M2BF62 InterPro	729

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ddx3xa-201 (1) Ensembl	Havana	5007 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ddx3xa-202 (1) Ensembl	Havana	454 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations