Gene

nansa

ID
ZDB-GENE-030131-1500
Name
N-acetylneuraminic acid synthase a
Symbol
nansa Nomenclature History
Previous Names
  • nans
  • fb73c01
  • wu:fb73c01
  • zgc:77126 (1)
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have catalytic activity. Involved in embryonic skeletal system development. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Genevieve-type. Is expressed in several structures, including alar plate midbrain region; axis; digestive system; hatching gland; and polster. Orthologous to human NANS (N-acetylneuraminate synthase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from van Karnebeek et al., 2016
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nansa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
spondyloepimetaphyseal dysplasia, Genevieve-type Alliance Spondyloepimetaphyseal dysplasia, Genevieve type 610442
Associated With nansa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006190 Antifreeze-like/N-acetylneuraminic acid synthase C-terminal
Domain IPR013132 N-acetylneuraminic acid synthase, N-terminal
Domain IPR013974 SAF domain
Family IPR006013 Antifreeze, type III
Homologous_superfamily IPR013785 Aldolase-type TIM barrel
Homologous_superfamily IPR036732 Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain superfamily
Domain Details Per Protein
Protein Length Aldolase-type TIM barrel Antifreeze-like/N-acetylneuraminic acid synthase C-terminal Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain superfamily Antifreeze, type III N-acetylneuraminic acid synthase, N-terminal SAF domain
UniProtKB:Q6P0K4 359
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations