Gene
serpina1
- ID
- ZDB-GENE-030131-1421
- Name
- serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
- Symbol
- serpina1 Nomenclature History
- Previous Names
-
- wu:fb61c07
- wu:fb71a09
- zgc:153807
- zgc:158145
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be active in extracellular space. Is expressed in blood and lapillus. Human ortholog(s) of this gene implicated in several diseases, including alpha 1-antitrypsin deficiency; artery disease (multiple); chronic obstructive pulmonary disease (multiple); inflammatory bowel disease (multiple); and liver disease (multiple). Orthologous to several human genes including SERPINA1 (serpin family A member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| alpha 1-antitrypsin deficiency | Alliance | Emphysema due to AAT deficiency | 613490 |
| alpha 1-antitrypsin deficiency | Alliance | Emphysema-cirrhosis, due to AAT deficiency | 613490 |
| alpha 1-antitrypsin deficiency | Alliance | Hemorrhagic diathesis due to antithrombin Pittsburgh | 613490 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023795 | Serpin, conserved site |
| Domain | IPR023796 | Serpin domain |
| Family | IPR000215 | Serpin family |
| Homologous_superfamily | IPR036186 | Serpin superfamily |
| Homologous_superfamily | IPR042178 | Serpin superfamily, domain 1 |
| Homologous_superfamily | IPR042185 | Serpin superfamily, domain 2 |
Domain Details Per Protein
| Protein | Additional Resources | Length | Serpin, conserved site | Serpin domain | Serpin family | Serpin superfamily | Serpin superfamily, domain 1 | Serpin superfamily, domain 2 |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6YU45 | InterPro | 433 | ||||||
| UniProtKB:Q5SPJ4 | InterPro | 429 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
serpina1-201
(1)
|
Ensembl | 1,650 nt | ||
| mRNA |
serpina1-202
(1)
|
Ensembl | 1,392 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-121D13 | ||
| Encodes | EST | fb61c07 | ||
| Encodes | EST | fb71a09 | ||
| Encodes | EST | IMAGE:6997096 | ||
| Encodes | cDNA | MGC:153807 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158145 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001077758 (1) | 1412 nt | ||
| Genomic | GenBank:AL845550 (1) | 163676 nt | ||
| Polypeptide | UniProtKB:A0A8M6YU45 (1) | 433 aa |
- Jin, Q., Hu, Y., Gao, Y., Zheng, J., Chen, J., Gao, C., Peng, J. (2023) Hhex and Prox1a synergistically dictate the hepatoblast to hepatocyte differentiation in zebrafish. Biochemical and Biophysical Research Communications. 686:149182149182
- Park, K.H., Gooz, M., Ye, Z.W., Zhang, J., Beeson, G.C., Rockey, D.C., Kim, S.H. (2021) Flavin Adenine Dinucleotide Depletion Caused by electron transfer flavoprotein subunit alpha Haploinsufficiency Leads to Hepatic Steatosis and Injury in Zebrafish. Hepatology communications. 5:976-991
- So, J., Kim, M., Lee, S.H., Ko, S., Lee, D.A., Park, H., Azuma, M., Parsons, M.J., Prober, D., Shin, D. (2020) Attenuating the EGFR-ERK-SOX9 axis promotes liver progenitor cell-mediated liver regeneration in zebrafish. Hepatology (Baltimore, Md.). 73(4):1494-1508
- Kalka, M., Markiewicz, N., Ptak, M., Sone, E.D., Ożyhar, A., Dobryszycki, P., Wojtas, M. (2019) In vivo and in vitro analysis of starmaker activity in zebrafish otolith biomineralization. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(6):6877-6886
- Park, K.H., Kim, S.H. (2019) Low dose of chronic ethanol exposure in adult zebrafish induces hepatic steatosis and injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 117:109179
- Park, K.H., Ye, Z.W., Zhang, J., Hammad, S.M., Townsend, D.M., Rockey, D.C., Kim, S.H. (2019) 3-ketodihydrosphingosine reductase mutation induces steatosis and hepatic injury in zebrafish. Scientific Reports. 9:1138
- Park, K.H., Ye, Z.W., Zhang, J., Kim, S.H. (2019) Palmitic Acid-Enriched Diet Induces Hepatic Steatosis and Injury in Adult Zebrafish. Zebrafish. 16(6):497-504
- Schmid, S., Fent, K. (2019) 17β-Estradiol and the glucocorticoid clobetasol propionate affect the blood coagulation cascade in zebrafish. Environmental pollution (Barking, Essex : 1987). 259:113808
- van der Helm, D., Groenewoud, A., de Jonge-Muller, E.S.M., Barnhoorn, M.C., Schoonderwoerd, M.J.A., Coenraad, M.J., Hawinkels, L.J.A.C., Snaar-Jagalska, B.E., van Hoek, B., Verspaget, H.W. (2018) Mesenchymal stromal cells prevent progression of liver fibrosis in a novel zebrafish embryo model. Scientific Reports. 8:16005
- Zhang, Q., Ji, C., Ren, J., Zhang, Q., Dong, X., Zu, Y., Jia, L., Li, W. (2018) Differential transcriptome analysis of zebrafish (Danio rerio) larvae challenged by Vibrio parahaemolyticus. Journal of fish diseases. 41(7):1049-1062
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