Gene
nqo1
- ID
- ZDB-GENE-030131-1226
- Name
- NAD(P)H dehydrogenase, quinone 1
- Symbol
- nqo1 Nomenclature History
- Previous Names
-
- wu:fb63c10
- zgc:77191
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable NAD(P)H dehydrogenase (quinone) activity. Acts upstream of or within cellular response to xenobiotic stimulus. Predicted to be active in cytosol. Is expressed in several structures, including head; liver; neuromast; pleuroperitoneal region; and yolk. Human ortholog(s) of this gene implicated in several diseases, including hematologic cancer (multiple); hypertension; lung disease (multiple); macular degeneration; and small cell carcinoma. Orthologous to human NQO1 (NAD(P)H quinone dehydrogenase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6901454 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| w239 | Allele with one deletion | Unknown | Unknown | CRISPR |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Flavodoxin-like fold | Flavoprotein-like superfamily | NAD(P)H dehydrogenase (quinone) |
|---|---|---|---|---|---|
| UniProtKB:A0A2R8PW65 | InterPro | 289 | |||
| UniProtKB:Q6P0H2 | InterPro | 275 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-113K19 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6901454 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:77191 | ZFIN Curated Data | |
| Has Artifact | EST | fb63c10 | ||
| Has Artifact | EST | fb64c10 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001204272 (1) | 1544 nt | ||
| Genomic | GenBank:BX255936 (2) | 93340 nt | ||
| Polypeptide | UniProtKB:A0A2R8PW65 (1) | 289 aa |
- Badenetti, L., Manzoli, R., Rubin, M., Cozza, G., Moro, E. (2023) Monitoring Nrf2/ARE Pathway Activity with a New Zebrafish Reporter System. International Journal of Molecular Sciences. 24(7):
- Chang, S.H., Giong, H.K., Kim, D.Y., Kim, S., Oh, S., Yun, U.J., Lee, J.S., Park, K.W. (2023) Activation of Nrf2 by sulfuretin stimulates chondrocyte differentiation and increases bone lengths in zebrafish. BMB reports. 56:496501496-501
- Le Mentec, H., Monniez, E., Legrand, A., Monvoisin, C., Lagadic-Gossmann, D., Podechard, N. (2023) A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation. International Journal of Molecular Sciences. 24(4):
- Ravindra, J., Ug, Y., Pandyanda Nanjappa, D., Kalladka, K., Dhakal, R., Chakraborty, A., Chakraborty, G. (2023) Allicin extracted from Allium sativum shows potent anti-cancer and antioxidant properties in zebrafish. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 169:115854115854
- Wu, Y., Lim, Y.W., Stroud, D.A., Martel, N., Hall, T.E., Lo, H.P., Ferguson, C., Ryan, M.T., McMahon, K.A., Parton, R.G. (2023) Caveolae sense oxidative stress through membrane lipid peroxidation and cytosolic release of CAVIN1 to regulate NRF2. Developmental Cell. 58(5):376-397.e4
- Xia, H., Cheng, X., Cao, M., Sun, X., He, F., Yao, X., Liu, H. (2023) Tetrahydroxystilbene Glucoside Attenuates Oxidative Stress-Induced Aging by Regulating Oxidation Resistance and Inflammation in Larval Zebrafish. Zebrafish. 20:556655-66
- Xu, F.H., Qiu, Y.Z., Zhang, Y., Yang, F.H., Ji, M.M., Liu, K.C., Jin, M., Zhang, S.S., Li, B. (2023) The molecular mechanism of three novel peptides from C-phycocyanin alleviates MPTP-induced Parkinson's disease-like pathology in zebrafish. Food & function. 14(13):6157-6171
- Xu, Y., Peng, T., Zhou, Q., Zhu, J., Liao, G., Zou, F., Meng, X. (2023) Evaluation of the oxidative toxicity induced by lead, manganese, and cadmium using genetically modified nrf2a-mutant zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 266:109550
- Chen, C., He, M., Li, X., Yu, L., Liu, Y., Yang, Y., Li, L., Jia, J., Li, B. (2022) H2O2/DEM-Promoted Maft Promoter Demethylation Drives Nrf2/ARE Activation in Zebrafish. Life (Basel, Switzerland). 12(9)
- Chen, J., Chen, Y., Zheng, Y., Zhao, J., Yu, H., Zhu, J. (2022) The Relationship between Procyanidin Structure and Their Protective Effect in a Parkinson's Disease Model. Molecules. 27(15)
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