Gene

setd6

ID

ZDB-GENE-030131-1067

Name

SET domain containing 6, protein lysine methyltransferase

Symbol

setd6 Nomenclature History

Previous Names

wu:fb58f11
zgc:55627 (1)

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have NF-kappaB binding activity and protein-lysine N-methyltransferase activity. Predicted to be involved in negative regulation of NF-kappaB transcription factor activity; peptidyl-lysine monomethylation; and regulation of inflammatory response. Predicted to localize to nucleus. Is expressed in several structures, including alar plate midbrain region; anterior neural keel; immature eye; midbrain; and pectoral fin musculature. Orthologous to human SETD6 (SET domain containing 6, protein lysine methyltransferase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55627 (13 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With setd6 Human Ortholog

No data available

Associated With setd6 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001214	SET domain
Domain	IPR015353	Rubisco LSMT, substrate-binding domain
Domain	IPR044430	SETD6, SET domain
Family	IPR011383	N-lysine methyltransferase SETD6
Family	IPR050600	SETD3/SETD6 methyltransferase
Homologous_superfamily	IPR036464	Rubisco LSMT, substrate-binding domain superfamily
Homologous_superfamily	IPR046341	SET domain superfamily