Gene

smc2

ID

ZDB-GENE-030131-105

Name

structural maintenance of chromosomes 2

Symbol

smc2 Nomenclature History

Previous Names

fb92e05
hm:zeh1628
wu:fb92e05 (1)
zeh1628
zgc:55326 (1)

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable chromatin binding activity. Predicted to be involved in mitotic chromosome condensation. Predicted to act upstream of or within chromosome condensation. Predicted to be located in chromosome and nucleus. Predicted to be part of condensin complex. Predicted to be active in chromatin and condensed chromosome. Is expressed in several structures, including blood vessel; digestive system; nervous system; optic vesicle; and pectoral fin. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human SMC2 (structural maintenance of chromosomes 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

16 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55326 (9 images)
IMAGE:7165175 (15 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from Li et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With smc2 Human Ortholog

No data available

Associated With smc2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003395	RecF/RecN/SMC, N-terminal
Domain	IPR010935	SMCs flexible hinge
Domain	IPR027120	Smc2, ATP-binding cassette domain
Family	IPR024704	Structural maintenance of chromosomes protein
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036277	SMCs flexible hinge superfamily