Gene
esr2b
- ID
- ZDB-GENE-030116-1
- Name
- estrogen receptor 2b
- Symbol
- esr2b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Exhibits estrogen receptor activity; nuclear receptor activity; and steroid hormone binding activity. Involved in response to estrogen. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); arthritis (multiple); autoimmune hypersensitivity disease (multiple); hypospadias; and neurodegenerative disease (multiple). Is expressed in several structures, including forebrain; head; liver; male organism; and pleuroperitoneal region. Orthologous to human ESR2 (estrogen receptor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 33 figures from 25 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103724 (1 image)
- aj414566 (14 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ovarian dysgenesis 8 | Alliance | ?Ovarian dysgenesis 8 | 618187 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Domain | IPR021064 | Estrogen receptor beta-like, N-terminal |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR024178 | Estrogen receptor/oestrogen-related receptor |
| Family | IPR028355 | Estrogen receptor beta/gamma |
| Family | IPR050200 | Nuclear hormone receptor family NR3 subfamily |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Estrogen receptor beta/gamma | Estrogen receptor beta-like, N-terminal | Estrogen receptor/oestrogen-related receptor | Nuclear hormone receptor | Nuclear hormone receptor family NR3 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B359
|
600 | |||||||||
|
UniProtKB:Q5PR29
|
592 | |||||||||
|
UniProtKB:B8JJL3
|
592 |
Interactions and Pathways
No data available
Plasmids
No data available