Gene
phex
- ID
- ZDB-GENE-030103-2
- Name
- phosphate regulating endopeptidase homolog, X-linked
- Symbol
- phex Nomenclature History
- Previous Names
-
- wu:fx03e08
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in lapillus. Human ortholog(s) of this gene implicated in X-linked hypophosphatemic rickets. Orthologous to human PHEX (phosphate regulating endopeptidase X-linked).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| X-linked hypophosphatemic rickets | Alliance | Hypophosphatemic rickets, X-linked dominant | 307800 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR008753 | Peptidase M13, N-terminal domain |
| Domain | IPR018497 | Peptidase M13, C-terminal domain |
| Family | IPR000718 | Peptidase M13 |
| Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
| Homologous_superfamily | IPR042089 | Peptidase M13, domain 2 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Metallopeptidase, catalytic domain superfamily | Peptidase M13 | Peptidase M13, C-terminal domain | Peptidase M13, domain 2 | Peptidase M13, N-terminal domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:F1R6K1 | InterPro | 745 | |||||
| UniProtKB:A0A286Y855 | InterPro | 727 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-225N3 | ZFIN Curated Data | |
| Encodes | EST | fx03e08 | ||
| Encodes | EST | IMAGE:7151798 | ||
| Encodes | cDNA | MGC:162949 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001320330 (1) | 2641 nt | ||
| Genomic | GenBank:BX537285 (1) | 150691 nt | ||
| Polypeptide | UniProtKB:F1R6K1 (1) | 745 aa |
- Cotti, S., Di Biagio, C., Huysseune, A., Koppe, W., Forlino, A., Witten, P.E. (2024) Matrix first, minerals later: fine-tuned dietary phosphate increases bone formation in zebrafish. JBMR plus. 8:ziae081ziae081
- Nie, C.H., Wan, S.M., Chen, Y.L., Huysseune, A., Wu, Y.M., Zhou, J.J., Hilsdorf, A.W.S., Wang, W.M., Witten, P.E., Lin, Q., Gao, Z.X. (2022) Single-cell transcriptomes and runx2b-/- mutants reveal the genetic signatures of intermuscular bone formation in zebrafish. National science review. 9:nwac152nwac152
- Ghilardi, A., Diana, A., Prosperi, L., Del Giacco, L. (2020) Expression pattern of the small muscle protein, X-linked (smpx) gene during zebrafish embryonic and larval developmental stages. Gene expression patterns : GEP. 36:119110
- Kalka, M., Markiewicz, N., Ptak, M., Sone, E.D., Ożyhar, A., Dobryszycki, P., Wojtas, M. (2019) In vivo and in vitro analysis of starmaker activity in zebrafish otolith biomineralization. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(6):6877-6886
- Liang, S.T., Chen, J.R., Tsai, J.J., Lai, Y.H., Hsiao, C.D. (2019) Overexpression of Notch Signaling Induces Hyperosteogeny in Zebrafish. International Journal of Molecular Sciences. 20(15)
- Chen, J.R., Lai, Y.H., Tsai, J.J., Hsiao, C.D. (2017) Live Fluorescent Staining Platform for Drug-Screening and Mechanism-Analysis in Zebrafish for Bone Mineralization. Molecules. 22(12)
- Suarez-Bregua, P., Saxena, A., Bronner, M.E., Rotllant, J. (2017) Targeted Pth4-expressing cell ablation impairs skeletal mineralization in zebrafish. PLoS One. 12:e0186444
- Suarez-Bregua, P., Torres-Nuñez, E., Saxena, A., Guerreiro, P., Braasch, I., Prober, D.A., Moran, P., Cerda-Reverter, J.M., Du, S.J., Adrio, F., Power, D.M., Canario, A.V., Postlethwait, J.H., Bronner, M.E., Cañestro, C., Rotllant, J. (2017) Pth4, an ancient parathyroid hormone lost in eutherian mammals, reveals a new brain-to-bone signaling pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31:569-583
- Jeradi, S., Hammerschmidt, M. (2016) Retinoic acid-induced premature osteoblast-to-preosteocyte transitioning has multiple effects on calvarial development. Development (Cambridge, England). 143(7):1205-16
- Kang, J., Hu, J., Karra, R., Dickson, A.L., Tornini, V.A., Nachtrab, G., Gemberling, M., Goldman, J.A., Black, B.L., Poss, K.D. (2016) Modulation of tissue repair by regeneration enhancer elements. Nature. 532(7598):201-6
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