Gene
drd2a
- ID
- ZDB-GENE-021119-2
- Name
- dopamine receptor D2a
- Symbol
- drd2a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor activity and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Predicted to be involved in G protein-coupled receptor signaling pathway; negative regulation of cytosolic calcium ion concentration; and negative regulation of glutamatergic synaptic transmission. Predicted to act upstream of or within dopamine receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in glutamatergic synapse and presynaptic membrane. Is expressed in nervous system. Human ortholog(s) of this gene implicated in several diseases, including end stage renal disease; mental depression; migraine with aura; obesity; and type 2 diabetes mellitus. Orthologous to human DRD2 (dopamine receptor D2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Dopamine D2 receptor | Dopamine receptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M3B0Z4
|
420 | ||||
|
UniProtKB:Q8AWE0
|
448 |
Interactions and Pathways
No data available
Plasmids
No data available