Gene

guk1b

ID

ZDB-GENE-020916-1

Name

guanylate kinase 1b

Symbol

guk1b Nomenclature History

Previous Names

guk1
zgc:73128
zgc:73217

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to enable guanylate kinase activity. Predicted to act upstream of or within phosphorylation and purine nucleotide metabolic process. Predicted to be located in membrane. Predicted to be active in cytosol. Is expressed in epiphysis; retina; retinal outer nuclear layer; and retinal photoreceptor layer. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome-21. Orthologous to human GUK1 (guanylate kinase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:73128 (14 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With guk1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
mitochondrial DNA depletion syndrome-21	Alliance	Mitochondrial DNA depletion syndrome 21	621071

Associated With guk1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020590	Guanylate kinase, conserved site
Domain	IPR008144	Guanylate kinase-like domain
Domain	IPR008145	Guanylate kinase/L-type calcium channel beta subunit
Family	IPR017665	Guanylate kinase
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	Guanylate kinase	Guanylate kinase, conserved site	Guanylate kinase-like domain	Guanylate kinase/L-type calcium channel beta subunit	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:Q6PC32 InterPro	223
UniProtKB:B8JJJ6 InterPro	197

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	guk1b-201 (1) Ensembl	Ensembl	1,265 nt	Select Tool ZFIN BLAST
mRNA	guk1b-202 (1) Ensembl	Ensembl	1,200 nt	Select Tool ZFIN BLAST
ncRNA	guk1b-002 (1) Ensembl	Ensembl	1,512 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations