Gene

caspb

ID

ZDB-GENE-020812-1

Name

caspase b

Symbol

caspb Nomenclature History

Previous Names

caspy2
casp19a (1)
zgc:109807

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Exhibits cysteine-type endopeptidase activity; enzyme activator activity; and lipopolysaccharide binding activity. Involved in defense response to bacterium; positive regulation of apoptotic process; and pyroptosis. Predicted to localize to cytoplasm. Is expressed in several structures, including digestive system; gill; immune system; integument; and muscle cell. Orthologous to human CASP4 (caspase 4) and CASP5 (caspase 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

16 figures from 9 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:109807 (5 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With caspb Human Ortholog

No data available

Associated With caspb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR016129	Peptidase family C14A, His active site
Active_site	IPR033139	Peptidase family C14A, cysteine active site
Domain	IPR001309	Peptidase C14, p20 domain
Domain	IPR002138	Peptidase C14, caspase non-catalytic subunit p10
Domain	IPR004020	DAPIN domain
Domain	IPR011600	Peptidase C14, caspase domain
Domain	IPR015917	Peptidase C14A, caspase catalytic domain
Homologous_superfamily	IPR011029	Death-like domain superfamily
Homologous_superfamily	IPR029030	Caspase-like domain superfamily

Domain Details Per Protein

Protein	Length	Caspase-like domain superfamily	DAPIN domain	Death-like domain superfamily	Peptidase C14A, caspase catalytic domain	Peptidase C14, caspase domain	Peptidase C14, caspase non-catalytic subunit p10	Peptidase C14, p20 domain	Peptidase family C14A, cysteine active site	Peptidase family C14A, His active site
UniProtKB:Q504J1 InterPro	404

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	caspb-201 (1) Ensembl	Ensembl		1,819 nt	Select Tool
mRNA	caspb-202 (1) Ensembl	Ensembl		1,238 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl
Note: Removed orthology to human CASP1 curated from Woods et al. 2005. Not clear if CASP1 or CASP5 is ortholog.

Citations