Gene
robo4
- ID
- ZDB-GENE-020809-1
- Name
- roundabout, axon guidance receptor, homolog 4 (Drosophila)
- Symbol
- robo4 Nomenclature History
- Previous Names
-
- sc:d0823
- wu:fa16f09
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have cell-cell adhesion mediator activity. Involved in several processes, including plasma membrane bounded cell projection assembly; positive regulation of Rac protein signal transduction; and positive regulation of cell-matrix adhesion. Localizes to intrinsic component of plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; neural tube; optic cup; and vestibuloauditory system. Human ortholog(s) of this gene implicated in bicuspid aortic valve disease. Orthologous to human ROBO4 (roundabout guidance receptor 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d823 (24 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| aortic valve disease 3 | Alliance | Aortic valve disease 3 | 618496 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013098 | Immunoglobulin I-set |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A4JYG5
|
591 | ||||||||
|
UniProtKB:A0A8M2BK13
|
1093 | ||||||||
|
UniProtKB:F1RE66
|
1134 |
Interactions and Pathways
No data available
Plasmids
No data available