Gene
dcc
- ID
- ZDB-GENE-011101-2
- Name
- DCC netrin 1 receptor
- Symbol
- dcc Nomenclature History
- Previous Names
-
- spaced out
- spo
- zdcc (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables netrin receptor activity involved in chemoattraction. Acts upstream of or within with a positive effect on commissural neuron axon guidance. Acts upstream of or within neuron differentiation and regulation of axon extension. Predicted to be located in membrane. Is expressed in several structures, including brain; neural tube; pleuroperitoneal region; posterior neural rod; and primary motor neurons. Human ortholog(s) of this gene implicated in colorectal cancer; congenital mirror movement disorder; esophageal cancer; and esophagus squamous cell carcinoma. Orthologous to human DCC (DCC netrin 1 receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 20 figures from 10 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
| esophageal cancer | Alliance | Esophageal carcinoma, somatic | 133239 |
| Gaze palsy, familial horizontal, with progressive scoliosis, 2 | 617542 | ||
| Mirror movements 1 and/or agenesis of the corpus callosum | 157600 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR010560 | Neogenin, C-terminal |
| Domain | IPR013098 | Immunoglobulin I-set |
| Family | IPR009138 | Neural cell adhesion |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Neogenin, C-terminal | Neural cell adhesion |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0G2KXQ3
|
757 | ||||||||||
|
UniProtKB:Q49BB0
|
1421 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available