Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-010906-1
Gene Name: acetylcholinesterase
Gene Symbol: ache
Previous Names: zgc:92550, ziehharmonika (1), zim (1)
Nomenclature History
GENE EXPRESSION
All Expression Data: 13 figures from 8 publications
Directly Submitted Expression Data: 6 figures (6 images) from Thisse et al., 2005 [eu3]
Wild-type Stages, Structures: Blastula:Sphere (4.0h-4.33h) to Adult (90d-730d, breeding adult)
  brain, hindbrain, midbrain, myotome (all 9) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 9 genotypes
Alleles: sb55, tf222a, tm205, tm206
Knockdown reagents: MO1-ache (1)
PHENOTYPE
Data: 16 figures from 6 publications
Observed in: acetylcholinesterase activity, apoptotic process, associative learning, axon guidance (all 27) expand

Phenotype of Human Orthologue OMIM Phenotype ID
[Blood group, Yt system] 112100
GENE ONTOLOGY
Ontology GO Term
Biological Process acetylcholine catabolic process (more)
Cellular Component cell junction (more)
Molecular Function acetylcholinesterase activity (more)
GO Terms (all 21)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000997 (1)
  • InterPro:IPR002018 (1)
  • InterPro:IPR014788 (1)
  • InterPro:IPR019819 (1)
  • InterPro:IPR019826 (1)
  • PROSITE:PS00122 (1)
  • PROSITE:PS00941 (1)
  • Pfam:PF00135 (1)
  • Pfam:PF08674 (1)
  • EC:3.1.1.7 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ache-001 (1) 4795
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM ache
    Tg(Cca.Actb:YFP,5xUAS:ache)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    ache Contained in: [BAC] CH211-153N19 (1) (order this), CH211-196F2 (1) (order this)
    ache Encodes: [EST] eu3 (1)
    [cDNA] MGC:92550 (1) (order this), MGC:195318 (1) (order this), MGC:195325 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131846 (1) 2556 bp
    Genomic GenBank:BX470232 (1) 194721 bp
    Select Tool
    Polypeptide UniProtKB:B3DKL4 (1) 634 aa
    Sequence Clusters UniGene:133438 (1)
    Sequence Information (all 22)
    OTHER ache GENE PAGES
  • Gene:114549 (1)
  • VEGA:OTTDARG00000020126 (1)
  • Ensembl(Zv9):ENSDARG00000031796 (1)
  • MAPPING INFORMATION
    Chr: 7 Details View Map: Merged   Individual Panels
    ORTHOLOGY
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL
    Zebrafish ache 7  
    Human ACHE 7 (7q22)
  • OMIM:100740
  • Gene:43
  • Mouse Ache 5 ( 76.32 cM)
  • MGI:87876
  • Gene:11423
  • CITATIONS (49)