ZFIN ID: ZDB-GENE-010906-1
Gene Name: acetylcholinesterase
Gene Symbol: ache
Previous Names: zgc:92550, ziehharmonika (1), zim (1)
Location: Chr: 7   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 15 figures from 10 publications
Directly Submitted Expression Data: 6 figures (6 images) from Thisse et al., 2005 [eu3]
Wild-type Stages, Structures: Blastula:Sphere (4.0h-4.33h) to Adult (90d-730d, breeding adult)
  brain, hindbrain, interpeduncular nucleus tegmentum, midbrain (all 11) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 9 Genotypes
Knockdown reagents: MO1-ache (1)

Allele Type Mutagen Suppliers
sb55 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tf222a Point Mutation
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Nüsslein-Volhard Lab
  • tm205 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Nüsslein-Volhard Lab
  • European Zebrafish Resource Center (EZRC) (order this)
  • tm206 Unknown ENU
    PHENOTYPE
    Data: 16 figures from 6 publications
    Observed in: acetylcholinesterase activity, apoptotic process, associative learning, axon guidance (all 27) expand
    DISEASE ASSOCIATED WITH ache HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    [Blood group, Yt system] 112100
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process acetylcholine catabolic process (more)
    Cellular Component cell junction (more)
    Molecular Function acetylcholinesterase activity (more)
    GO Terms (all 43)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000997 (1)
  • InterPro:IPR002018 (1)
  • InterPro:IPR014788 (1)
  • InterPro:IPR019819 (1)
  • InterPro:IPR019826 (1)
  • InterPro:IPR029058 (1)
  • PROSITE:PS00122 (1)
  • PROSITE:PS00941 (1)
  • Pfam:PF00135 (1)
  • Pfam:PF08674 (1)
  • EC:3.1.1.- (1)
  • EC:3.1.1.7 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ache-001 (1) 4795
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ache
    Tg(Cca.Actb:YFP,5xUAS:ache)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    ache Contained in: [BAC] CH211-153N19 (1) (order this), CH211-196F2 (1) (order this)
    ache Encodes: [EST] eu3 (1)
    [cDNA] MGC:92550 (1) (order this), MGC:195318 (1) (order this), MGC:195325 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131846 (1) 2556 bp
    Genomic GenBank:BX470232 (1) 194721 bp
    Select Tool
    Polypeptide UniProtKB:B3DKL4 (1) 634 aa
    Sequence Clusters UniGene:133438 (1)
    Sequence Information (all 22)
    OTHER ache GENE PAGES
  • Gene:114549 (1)
  • VEGA:OTTDARG00000020126 (1)
  • Ensembl(Zv9):ENSDARG00000031796 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish ache 7  
    Human ACHE 7 (7q22)
  • OMIM:100740
  • Gene:43
  • Mouse Ache 5 ( 76.32 cM)
  • MGI:87876
  • Gene:11423
  • Orthology Details
    CITATIONS (54)