ZFIN ID: ZDB-GENE-010906-1
Gene Name: acetylcholinesterase
Gene Symbol: ache
Previous Names: zgc:92550, ziehharmonika (1), zim (1)
Location: Chr: 7 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 15 figures from 10 publications
Directly Submitted Expression Data: 6 figures (6 images) from Thisse et al., 2005 [eu3]
Wild-type Stages, Structures: Blastula:Sphere (4.0h-4.33h) to Adult (90d-730d, breeding adult)
  brain, hindbrain, interpeduncular nucleus tegmentum, midbrain (all 11) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa31572 Point Mutation Unknown Unknown ENU
sa40891 Point Mutation Unknown Unknown ENU
sb55 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tf222a Point Mutation Unknown Missense
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • tm205 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tm206 Unknown Unknown Unknown ENU
    Targeting reagents: MO1-ache (1)
    PHENOTYPE
    Data: 16 figures from 6 publications
    Observed in: acetylcholinesterase activity, apoptotic process, associative learning, axon guidance (all 27) expand
    DISEASE ASSOCIATED WITH ache HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    [Blood group, Yt system] 112100
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process acetylcholine catabolic process (more)
    Cellular Component cell junction (more)
    Molecular Function acetylcholinesterase activity (more)
    GO Terms (all 41)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000997 (1)
  • InterPro:IPR002018 (1)
  • InterPro:IPR014788 (1)
  • InterPro:IPR019819 (1)
  • InterPro:IPR019826 (1)
  • InterPro:IPR029058 (1)
  • PROSITE:PS00122 (1)
  • PROSITE:PS00941 (1)
  • Pfam:PF00135 (1)
  • Pfam:PF08674 (1)
  • EC:3.1.1.- (1)
  • EC:3.1.1.7 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ache-001 (1) 4795
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM ache
    Tg(Cca.Actb:YFP,5xUAS:ache)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    acheContained in: [BAC] CH211-153N19 (1) (order this), CH211-196F2 (1) (order this)
    acheEncodes: [EST] eu3 (1)
    [cDNA] MGC:92550 (1) (order this), MGC:195318 (1) (order this), MGC:195325 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131846 (1) 2556bp
    Genomic GenBank:BX470232 (1) 194721bp
    Select Tool
    Polypeptide UniProtKB:B3DKL4 (1) 634aa
    Sequence Clusters UniGene:133438 (1)
    Sequence Information (all 22)
    OTHER ache GENE PAGES
  • Gene:114549 (1)
  • VEGA:OTTDARG00000020126 (1)
  • Ensembl(GRCz10):ENSDARG00000031796 (1)
  • ORTHOLOGY for ache (Chr: 7)
    Species Symbol Chromosome Accession # Evidence
    Human ACHE 7
  • Gene:43
  • OMIM:100740
  • HGNC:108
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Mouse Ache 5
  • MGI:87876
  • Gene:11423
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (65)