Gene
cldn1
- ID
- ZDB-GENE-010328-11
- Name
- claudin 1
- Symbol
- cldn1 Nomenclature History
- Previous Names
-
- cldn19 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable structural molecule activity. Predicted to be involved in bicellular tight junction assembly and cell adhesion. Predicted to be located in cell junction and membrane. Predicted to be active in bicellular tight junction and plasma membrane. Is expressed in eye; female organism; gill; integument; and posterior intestine. Human ortholog(s) of this gene implicated in Crohn's disease and atopic dermatitis. Orthologous to human CLDN1 (claudin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis | 607626 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Claudin | Claudin, conserved site | PMP-22/EMP/MP20/Claudin |
|---|---|---|---|---|
|
UniProtKB:Q90XQ8
|
210 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- Kollmar, et al. 2001. (Proc. Natl. Acad. Sci. 98:10196-10201.; ZDB-PUB-010912-21) originally suggested this gene was the ortholog of human CLDN19 based on amino acid sequence similarity. Subsequent analysis suggests it is the ortholog of human CLDN1 and mouse Cldn1.