ZFIN ID: ZDB-GENE-010306-3
Gene Name: slit homolog 2 (Drosophila)
Gene Symbol: slit2
Location: Chr: 1   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 13 figures from 11 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  central nervous system, forebrain, heart, hindbrain dorsal region (all 11) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 1 genotype
Alleles: la028107Tg, sa12974, sa15818, sa1772
Knockdown reagents: MO1-slit2 (1), MO2-slit2 (1), MO3-slit2 (1)
PHENOTYPE
Data: 2 figures from 2 publications
Observed in: endocardial progenitor cell migration to the midline involved in heart field formation, endocardium cell, endocardium, endocardium formation (all 5) expand
GENE ONTOLOGY
Ontology GO Term
Biological Process central nervous system projection neuron axonogenesis (more)
Cellular Component extracellular region (more)
Molecular Function calcium ion binding (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000152 (1)
  • InterPro:IPR000372 (1)
  • InterPro:IPR000483 (1)
  • InterPro:IPR000742 (1)
  • InterPro:IPR001611 (1)
  • InterPro:IPR001791 (1)
  • InterPro:IPR001881 (1)
  • InterPro:IPR003591 (1)
  • InterPro:IPR003645 (1)
  • InterPro:IPR006207 (1)
  • InterPro:IPR008985 (1)
  • InterPro:IPR009030 (1)
  • InterPro:IPR013032 (1)
  • InterPro:IPR013320 (1)
  • InterPro:IPR018097 (1)
  • PROSITE:PS00010 (1)
  • PROSITE:PS00022 (1)
  • PROSITE:PS01185 (1)
  • PROSITE:PS01186 (1)
  • PROSITE:PS01187 (1)
  • PROSITE:PS01225 (1)
  • PROSITE:PS50025 (1)
  • PROSITE:PS50026 (1)
  • PROSITE:PS51450 (1)
  • Pfam:PF00008 (1)
  • Pfam:PF00560 (1)
  • Pfam:PF01462 (1)
  • Pfam:PF01463 (1)
  • Pfam:PF02210 (1)
  • Pfam:PF12661 (1)
  • Pfam:PF13855 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA slit2-001 (1) 7426
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM slit2
    Tg(hsp70l:slit2-GFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    slit2 Contained in: [BAC] CH211-250N21 (1) (order this)
    [Fosmid] CH1073-144H23 (1) (order this), CH1073-162A7 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131735 (1) 4539 bp
    Genomic GenBank:CU896673 (1) 107021 bp
    Select Tool
    Polypeptide UniProtKB:F1QQE4 (1) 1512 aa
    Sequence Clusters UniGene:10489 (1)
    Sequence Information (all 22)
    OTHER slit2 GENE PAGES
  • Gene:80353 (1)
  • VEGA:OTTDARG00000030254 (1)
  • Ensembl(Zv9):ENSDARG00000004246 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA
    Zebrafish slit2 1  
    Human SLIT2 4 (4p15.2)
  • OMIM:603746
  • Gene:9353
  • Mouse Slit2 5 ( 26.05 cM)
  • MGI:1315205
  • Gene:20563
  • Orthology Details
    CITATIONS (41)