ZFIN ID: ZDB-GENE-010306-3
Gene Name: slit homolog 2 (Drosophila)
Gene Symbol: slit2
Location: Chr: 1 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 15 figures from 12 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  central nervous system, diencephalon, forebrain, forebrain neural tube anterior region (all 13) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS 
Allele Type Mutagen Suppliers
la028107Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1772 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12974 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15818 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents: MO1-slit2 (1), MO2-slit2 (1), MO3-slit2 (1)
    PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in: endocardial progenitor cell migration to the midline involved in heart field formation, endocardium cell, endocardium, endocardium formation (all 5) expand
    DISEASE ASSOCIATED WITH slit2 HUMAN ORTHOLOG No data available
    GENE ONTOLOGY 
    Ontology GO Term
    Biological Process central nervous system projection neuron axonogenesis (more)
    Cellular Component extracellular region (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000152 (1)
  • InterPro:IPR000372 (1)
  • InterPro:IPR000483 (1)
  • InterPro:IPR000742 (1)
  • InterPro:IPR001611 (1)
  • InterPro:IPR001791 (1)
  • InterPro:IPR001881 (1)
  • InterPro:IPR003590 (1)
  • InterPro:IPR003591 (1)
  • InterPro:IPR003645 (1)
  • InterPro:IPR006207 (1)
  • InterPro:IPR009030 (1)
  • InterPro:IPR013032 (1)
  • InterPro:IPR013320 (1)
  • InterPro:IPR018097 (1)
  • InterPro:IPR032675 (1)
  • PROSITE:PS00010 (1)
  • PROSITE:PS00022 (1)
  • PROSITE:PS01185 (1)
  • PROSITE:PS01186 (1)
  • PROSITE:PS01187 (1)
  • PROSITE:PS01225 (1)
  • PROSITE:PS50025 (1)
  • PROSITE:PS50026 (1)
  • PROSITE:PS51450 (1)
  • Pfam:PF00008 (1)
  • Pfam:PF01462 (1)
  • Pfam:PF01463 (1)
  • Pfam:PF02210 (1)
  • Pfam:PF12661 (1)
  • Pfam:PF13855 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA slit2-001 (1) 7426
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM slit2
    Tg(hsp70l:slit2-GFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS 
    slit2Contained in: [BAC] CH211-250N21 (1) (order this)
    [Fosmid] CH1073-144H23 (1) (order this), CH1073-162A7 (1) (order this)
    SEQUENCE INFORMATION 
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131735 (1) 4539bp
    Genomic GenBank:CU896673 (1) 107021bp
    Select Tool
    Polypeptide UniProtKB:F1QQE4 (1) 1512aa
    Sequence Clusters UniGene:10489 (1)
    Sequence Information (all 23)
    OTHER slit2 GENE PAGES 
  • Gene:80353 (1)
  • VEGA:OTTDARG00000030254 (1)
  • Ensembl(GRCz10):ENSDARG00000004246 (1)
  • ORTHOLOGY for slit2 (Chr: 1) 
    Species Symbol Chromosome Accession # Evidence
    Human SLIT2 4
  • Gene:9353
  • OMIM:603746
  • HGNC:11086
  • Amino acid sequence comparison (2)
    Mouse Slit2 5
  • MGI:1315205
  • Gene:20563
  • Amino acid sequence comparison (1)
    Download Curated Orthology
    CITATIONS (44)