ZFIN ID: ZDB-GENE-010306-3
Gene Name: slit homolog 2 (Drosophila)
Gene Symbol: slit2

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(Including Attributions)
Location: Chr: 1 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 16 figures from 13 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  central nervous system, diencephalon, diencephalon antero-medial region, forebrain (all 15) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028107Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa231 Point Mutation Unknown Premature Stop ENU
    sa1772 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12974 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15818 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa39610 Point Mutation Unknown Premature Stop ENU
    Targeting reagents: MO1-slit2 (1), MO2-slit2 (1), MO3-slit2 (1)
    PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in: endocardial progenitor cell migration to the midline involved in heart field formation, endocardium cell, endocardium, endocardium formation (all 5) expand
    DISEASE ASSOCIATED WITH slit2 HUMAN ORTHOLOGNo data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process central nervous system projection neuron axonogenesis (more)
    Cellular Component extracellular region (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000152 (1)
  • InterPro:IPR000372 (1)
  • InterPro:IPR000483 (1)
  • InterPro:IPR000742 (1)
  • InterPro:IPR001611 (1)
  • InterPro:IPR001791 (1)
  • InterPro:IPR001881 (1)
  • InterPro:IPR003591 (1)
  • InterPro:IPR003645 (1)
  • InterPro:IPR006207 (1)
  • InterPro:IPR009030 (1)
  • InterPro:IPR013032 (1)
  • InterPro:IPR013320 (1)
  • InterPro:IPR018097 (1)
  • InterPro:IPR032675 (1)
  • PROSITE:PS00010 (1)
  • PROSITE:PS00022 (1)
  • PROSITE:PS01185 (1)
  • PROSITE:PS01186 (1)
  • PROSITE:PS01187 (1)
  • PROSITE:PS01225 (1)
  • PROSITE:PS50025 (1)
  • PROSITE:PS50026 (1)
  • PROSITE:PS51450 (1)
  • Pfam:PF00008 (1)
  • Pfam:PF00054 (1)
  • Pfam:PF01462 (1)
  • Pfam:PF01463 (1)
  • Pfam:PF12661 (1)
  • Pfam:PF13855 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA slit2-001 (1) 7426
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM slit2
    Tg(hsp70l:slit2-GFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    slit2Contained in: [BAC] CH211-250N21 (1) (order this)
    [Fosmid] CH1073-144H23 (1) (order this), CH1073-162A7 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131735 (1) 4539bp
    Genomic GenBank:CU896673 (1) 107021bp
    Select Tool
    Polypeptide UniProtKB:F1QQE4 (1) 1512aa
    Sequence Clusters UniGene:10489 (1)
    Sequence Information (all 23)
    OTHER slit2 GENE PAGES
  • Gene:80353 (1)
  • VEGA:OTTDARG00000030254 (1)
  • Ensembl(GRCz10):ENSDARG00000004246 (1)
  • ORTHOLOGY for slit2 (Chr: 1)
    Species Symbol Chromosome Accession # Evidence
    Human SLIT2 4
  • Gene:9353
  • OMIM:603746
  • HGNC:11086
  • Amino acid sequence comparison (2)
    Mouse Slit2 5
  • MGI:1315205
  • Gene:20563
  • Amino acid sequence comparison (1)
    Download Curated Orthology
    CITATIONS (44)