ZFIN ID: ZDB-GENE-010306-3
Gene Name: slit homolog 2 (Drosophila)
Gene Symbol: slit2
Location: Chr: 1   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 15 figures from 12 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  central nervous system, diencephalon, forebrain, forebrain neural tube anterior region (all 13) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: slit2sa1772/sa1772(Tupfel long fin)
Knockdown reagents: MO1-slit2 (1), MO2-slit2 (1), MO3-slit2 (1)

Allele Type Mutagen Suppliers
la028107Tg Transgenic Insertion DNA
sa1772 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12974 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15818 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in: endocardial progenitor cell migration to the midline involved in heart field formation, endocardium cell, endocardium, endocardium formation (all 5) expand
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process central nervous system projection neuron axonogenesis (more)
    Cellular Component extracellular region (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000152 (1)
  • InterPro:IPR000372 (1)
  • InterPro:IPR000483 (1)
  • InterPro:IPR000742 (1)
  • InterPro:IPR001611 (1)
  • InterPro:IPR001791 (1)
  • InterPro:IPR001881 (1)
  • InterPro:IPR003591 (1)
  • InterPro:IPR003645 (1)
  • InterPro:IPR006207 (1)
  • InterPro:IPR009030 (1)
  • InterPro:IPR013032 (1)
  • InterPro:IPR013320 (1)
  • InterPro:IPR018097 (1)
  • PROSITE:PS00010 (1)
  • PROSITE:PS00022 (1)
  • PROSITE:PS01185 (1)
  • PROSITE:PS01186 (1)
  • PROSITE:PS01187 (1)
  • PROSITE:PS01225 (1)
  • PROSITE:PS50025 (1)
  • PROSITE:PS50026 (1)
  • PROSITE:PS51450 (1)
  • Pfam:PF00008 (1)
  • Pfam:PF00560 (1)
  • Pfam:PF01462 (1)
  • Pfam:PF01463 (1)
  • Pfam:PF02210 (1)
  • Pfam:PF12661 (1)
  • Pfam:PF13855 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA slit2-001 (1) 7426
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM slit2
    Tg(hsp70l:slit2-GFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    slit2 Contained in: [BAC] CH211-250N21 (1) (order this)
    [Fosmid] CH1073-144H23 (1) (order this), CH1073-162A7 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131735 (1) 4539 bp
    Genomic GenBank:CU896673 (1) 107021 bp
    Select Tool
    Polypeptide UniProtKB:F1QQE4 (1) 1512 aa
    Sequence Clusters UniGene:10489 (1)
    Sequence Information (all 22)
    OTHER slit2 GENE PAGES
  • Gene:80353 (1)
  • VEGA:OTTDARG00000030254 (1)
  • Ensembl(Zv9):ENSDARG00000004246 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA
    Zebrafish slit2 1  
    Human SLIT2 4 (4p15.2)
  • OMIM:603746
  • Gene:9353
  • Mouse Slit2 5 ( 26.05 cM)
  • MGI:1315205
  • Gene:20563
  • Orthology Details
    CITATIONS (41)