Gene
slit2
- ID
- ZDB-GENE-010306-3
- Name
- slit homolog 2 (Drosophila)
- Symbol
- slit2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable Roundabout binding activity and heparin binding activity. Acts upstream of or within several processes, including endocardial progenitor cell migration to the midline involved in heart field formation; negative regulation of axon extension; and nervous system development. Predicted to be located in extracellular region. Is expressed in several structures, including axial mesoderm; forebrain neural tube; hypochord; nervous system; and oocyte. Orthologous to human SLIT2 (slit guidance ligand 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR013032 | EGF-like, conserved site |
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000372 | Leucine-rich repeat N-terminal domain |
| Domain | IPR000483 | Cysteine-rich flanking region, C-terminal |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001791 | Laminin G domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR003645 | Follistatin-like, N-terminal |
| Domain | IPR006207 | Cystine knot, C-terminal |
| Family | IPR051355 | Notch and Slit guidance protein |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
| Repeat | IPR001611 | Leucine-rich repeat |
| Repeat | IPR003591 | Leucine-rich repeat, typical subtype |
Domain Details Per Protein
| Protein | Additional Resources | Length | Concanavalin A-like lectin/glucanase domain superfamily | Cysteine-rich flanking region, C-terminal | Cystine knot, C-terminal | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Follistatin-like, N-terminal | Growth factor receptor cysteine-rich domain superfamily | Laminin G domain | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat N-terminal domain | Leucine-rich repeat, typical subtype | Notch and Slit guidance protein |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PWQ2 | InterPro | 1527 | ||||||||||||||||
| UniProtKB:A0A8M9QD73 | InterPro | 1520 | ||||||||||||||||
| UniProtKB:A0A8M9Q7S3 | InterPro | 1544 | ||||||||||||||||
| UniProtKB:A0A8M9Q2G6 | InterPro | 1540 | ||||||||||||||||
| UniProtKB:A0A8M9Q7S7 | InterPro | 1533 | ||||||||||||||||
| UniProtKB:A0A8M9PWQ6 | InterPro | 1426 | ||||||||||||||||
| UniProtKB:A0A8M9PJ94 | InterPro | 1543 | ||||||||||||||||
| UniProtKB:A0A8M9Q7S9 | InterPro | 1516 | ||||||||||||||||
| UniProtKB:A0A8M9Q2G1 | InterPro | 1551 | ||||||||||||||||
| UniProtKB:A0A8M9QD69 | InterPro | 1536 | ||||||||||||||||
| UniProtKB:A0A8M9Q2H0 | InterPro | 1524 | ||||||||||||||||
| UniProtKB:Q9DE36 | InterPro | 1512 | ||||||||||||||||
| UniProtKB:A0A8M9PJA3 | InterPro | 1514 | ||||||||||||||||
| UniProtKB:A0A8M9QD64 | InterPro | 1547 | ||||||||||||||||
| UniProtKB:A0A8M9PWP8 | InterPro | 1542 | ||||||||||||||||
| UniProtKB:A0A8M9PJA0 | InterPro | 1532 | ||||||||||||||||
| UniProtKB:A0AB32TM76 | InterPro | 1539 | ||||||||||||||||
| UniProtKB:A0AB32TM78 | InterPro | 1538 | ||||||||||||||||
| UniProtKB:A0AB32TNE6 | InterPro | 1510 | ||||||||||||||||
| UniProtKB:A0AB32TNJ0 | InterPro | 1523 | ||||||||||||||||
| UniProtKB:A0AB32TQI8 | InterPro | 1536 | ||||||||||||||||
| UniProtKB:A0AB32TSR1 | InterPro | 1529 | ||||||||||||||||
| UniProtKB:A0AB32TU74 | InterPro | 1540 |
Interactions and Pathways
No data available
Plasmids
No data available