Gene

agxtb

ID
ZDB-GENE-010302-3
Name
alanine--glyoxylate and serine--pyruvate aminotransferase b
Symbol
agxtb Nomenclature History
Previous Names
  • agxt
  • wu:fb57d01
  • zgc:65930
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have alanine-glyoxylate transaminase activity and serine-pyruvate transaminase activity. Involved in cellular response to estrogen stimulus. Predicted to localize to mitochondrion and peroxisome. Human ortholog(s) of this gene implicated in primary hyperoxaluria type 1. Orthologous to human AGXT (alanine--glyoxylate and serine--pyruvate aminotransferase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With agxtb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
primary hyperoxaluria type 1 Alliance Hyperoxaluria, primary, type 1 259900
Associated With agxtb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR020578 Aminotransferase class-V, pyridoxal-phosphate binding site
Domain IPR000192 Aminotransferase class V domain
Family IPR024169 Serine-pyruvate aminotransferase/2-aminoethylphosphonate-pyruvate transaminase
Homologous_superfamily IPR015421 Pyridoxal phosphate-dependent transferase, major domain
Homologous_superfamily IPR015422 Pyridoxal phosphate-dependent transferase, small domain
Homologous_superfamily IPR015424 Pyridoxal phosphate-dependent transferase
Domain Details Per Protein
Protein Length Aminotransferase class V domain Aminotransferase class-V, pyridoxal-phosphate binding site Pyridoxal phosphate-dependent transferase Pyridoxal phosphate-dependent transferase, major domain Pyridoxal phosphate-dependent transferase, small domain Serine-pyruvate aminotransferase/2-aminoethylphosphonate-pyruvate transaminase
UniProtKB:Q6PHK4 423
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations