Gene
map2k6
- ID
- ZDB-GENE-010202-3
- Name
- mitogen-activated protein kinase kinase 6
- Symbol
- map2k6 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable MAP kinase kinase activity. Involved in positive regulation of p38MAPK cascade. Predicted to be located in several cellular components, including cytoplasm; cytoskeleton; and nucleus. Human ortholog(s) of this gene implicated in Pick's disease; cervical cancer; ovarian carcinoma; progressive supranuclear palsy; and restrictive cardiomyopathy. Orthologous to human MAP2K6 (mitogen-activated protein kinase kinase 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55210 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| mn0513Gt | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|
|
UniProtKB:A0A8M9Q8K0
|
416 | |||
|
UniProtKB:Q9DGE0
|
361 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
map2k6-201
(1)
|
Ensembl | 3,308 nt | ||
| mRNA |
map2k6-202
(1)
|
Ensembl | 4,253 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-105G4 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-113D16 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55210 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:86568 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192910 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001312870 (1) | 3308 nt | ||
| Genomic | GenBank:AL954682 (2) | 181276 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q8K0 (1) | 416 aa |
- Ding, Y., Lang, D., Yan, J., Bu, H., Li, H., Jiao, K., Yang, J., Ni, H., Morotti, S., Le, T., Clark, K.J., Port, J., Ekker, S.C., Cao, H., Zhang, Y., Wang, J., Grandi, E., Li, Z., Shi, Y., Li, Y., Glukhov, A.V., Xu, X. (2022) A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene. eLIFE. 11:
- Nam, Y.H., Rodriguez, I., Shin, S.W., Shim, J.H., Kim, N.W., Kim, M.C., Jeong, S.Y., Nuankaew, W., Hong, B.N., Kim, H., Kang, T.H. (2021) Characteristics of the New Insulin-Resistant Zebrafish Model. Pharmaceuticals (Basel, Switzerland). 14(7):
- Liu, R., Hu, X., Lü, A., Song, Y., Lian, Z., Sun, J., Sung, Y.Y. (2020) Proteomic Profiling of Zebrafish Challenged by Spring Viremia of Carp Virus Provides Insight into Skin Antiviral Response. Zebrafish. 17:91-103
- Qu, F., Tang, J., Liao, J., Chen, B., Song, P., Luo, W., Xiong, D., Liu, T., Gao, Q., Lu, S., Liu, Z. (2018) Mitogen-activated protein kinase kinase 6 is involved in the immune response to bacterial di-/tripeptide challenge in grass carp Ctenopharyngodon idella. Fish & shellfish immunology. 84:795-801
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Ding, Y., Long, P.A., Bos, J.M., Shih, Y.H., Ma, X., Sundsbak, R.S., Chen, J., Jiang, Y., Zhao, L., Hu, X., Wang, J., Shi, Y., Ackerman, M.J., Lin, X., Ekker, S.C., Redfield, M.M., Olson, T.M., Xu, X. (2016) A modifier screen identifies DNAJB6 as a cardiomyopathy susceptibility gene.. JCI insight. 1(14)
- Chou, C.M., Chen, Y.C., Su, S., Chen, G.D., Huang, K.Y., Lien, H.W., Huang, C.J., Cheng, C.H. (2015) Activation of MEK2 is sufficient to induce skin papilloma formation in transgenic zebrafish. Journal of Biomedical Science. 22:102
- Fodor, E., Zsigmond, A., Horváth, B., Molnár, J., Nagy, I., Tóth, G., Wilson, S.W., and Varga, M. (2013) Full transcriptome analysis of early dorsoventral patterning in zebrafish. PLoS One. 8(7):e70053
- De Wit, M., Keil, D., Remmerie, N., Ven, K.V., Brandhof, E.J., Knapen, D., Witters, E., and Coen, W.D. (2008) Molecular targets of TBBPA in zebrafish analysed through integration of genomic and proteomic approaches. Chemosphere. 74(1):96-105
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
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